ArticleMedical physics2012
Single-scan rest∕stress imaging (18)F-labeled flow tracers.
Article in Medical physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Technical evaluation of immediate back-to-back rest-stress positron emission tomography scanning withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Article
- Flurpiridaz F 18: First Approval.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025Review
- Impact of residual subtraction on myocardial blood flow and reserve estimates from rapid dynamic PET protocols.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- PET Parametric Imaging: Past, Present, and Future.IEEE transactions on radiation and plasma medical sciences · 2020Article
- Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique forCirculation. Cardiovascular imaging · 2020Article
- Quantification of PET Myocardial Blood Flow.Current cardiology reports · 2019Review
- Joint reconstruction of rest/stress myocardial perfusion SPECT.Physics in medicine and biology · 2018Article
- Searching for novel PET radiotracers: imaging cardiac perfusion, metabolism and inflammation.American journal of nuclear medicine and molecular imaging · 2018Review
- Rapid computation of single PET scan rest-stress myocardial blood flow parametric images by table look up.Medical physics · 2017Article
- Single-scan rest/stress imaging: validation in a porcine model withEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies.Physics in medicine and biology · 2017Article
- Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR.Physics in medicine and biology · 2017Article
- Article
- A Bayesian spatial temporal mixtures approach to kinetic parametric images in dynamic positron emission tomography.Medical physics · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe authors report a novel measurement strategy to obtain both rest and stress blood flow during a single, relatively short, scan session.
methodsMeasurement of rest-stress myocardial blood flow with long-lived tracers usually requires separate scan sessions to remove the confounding effects of residual radioactivity concentration in the blood and tissue. The innovation of this method is to treat the rest-stress scan as a single entity in which the flow parameters change due to pharmacological challenge. With this approach the fate of a tracer molecule is naturally accounted for, no matter if it was introduced during the rest or stress phase of the study. Two new dual-injection kinetic models are considered that represent the response to pharmacological stress as a transitional or transient increase of myocardial blood flow. The authors present the theory of the method followed by the specific application of the theory to (18)F-Flurpiridaz, a new myocardial flow-imaging agent.
resultsMyocardial blood flow was accurately and precisely estimated from a single-scan rest∕stress study for the long half-lived tracer (18)F-Flurpiridaz. By accounting for the time-dependence of the kinetic parameters, the proposed models achieved good accuracy and precision (5%) under different vasodilators and different ischemic states.
conclusionsDetailed simulations predict that accurate and precise rest-stress blood flow measurements can be obtained in 20-30 min.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.