ArticleBMC neurology2012
Risk of fractures in patients with multiple sclerosis: record-linkage study.
Article in BMC neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Multiple sclerosis increases fracture risk: a meta-analysis.BioMed research international · 2015Pooled it
- High dose vitamin D supplementation does not affect biochemical bone markers in multiple sclerosis - a randomized controlled trial.BMC neurology · 2017Trial
- Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis.Frontiers in neurology · 2022Article
- Spotlight on postural control in patients with multiple sclerosis.Degenerative neurological and neuromuscular disease · 2018Review
- Risk Factors, Epidemiology and Treatment Strategies for Metabolic Bone Disease in Patients with Neurological Disease.Current osteoporosis reports · 2016Review
- Effect of Anticholinergic Medications on Falls, Fracture Risk, and Bone Mineral Density Over a 10-Year Period.The Annals of pharmacotherapy · 2014Article
- The association between multiple sclerosis and fracture risk.International journal of clinical and experimental medicine · 2014Article
- Is there an increased risk of hip fracture in multiple sclerosis? Analysis of the Nationwide Inpatient Sample.Journal of multidisciplinary healthcare · 2014Article
- Promoting return of function in multiple sclerosis: An integrated approach.Multiple sclerosis and related disorders · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with multiple sclerosis (MS) have been reported to be at higher risk of fracture than other people. We sought to test this hypothesis in a large database of hospital admissions in England.
methodsWe analysed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999-2010). Rate ratios for fractures were determined, comparing fracture rates in a cohort of all people in England admitted with MS and rates in a comparison cohort.
resultsSignificantly elevated risk for all fractures was found in patients with MS (rate ratio (RR) = 1.99, 95% confidence interval (CI) = 1.93-2.05)). Risks were particularly high for femoral fractures (femoral neck fracture RR = 2.79 (2.65-2.93); femoral shaft fracture RR 6.69 (6.12-7.29)), and fractures of the tibia or ankle RR = 2.81 (2.66-2.96).
conclusionsPatients with MS have an increased risk of fractures. Caregivers should aim to optimize bone health in MS patients.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.