Trial reportJournal of clinical hypertension (Greenwich, Conn.)2012
Blood pressure measurement device, number and timing of visits, and intra-individual visit-to-visit variability of blood pressure.
Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic significance of visit-to-visit systolic blood pressure variability: a meta-analysis of 77,299 patients.Journal of clinical hypertension (Greenwich, Conn.) · 2015Pooled it
- Visit-to-visit variability of blood pressure and cardiovascular disease and all-cause mortality: a systematic review and meta-analysis.Hypertension (Dallas, Tex. : 1979) · 2014Pooled it
- Long-Term Blood Pressure Variability and Kidney Function in Participants of the ASPREE Trial.American journal of hypertension · 2022Trial
- China Stroke Primary Prevention Trial: Visit-to-Visit Systolic Blood Pressure Variability Is an Independent Predictor of Primary Stroke in Hypertensive Patients.Journal of the American Heart Association · 2017Trial
- Visit-to-Visit Variability of Blood Pressure and Coronary Heart Disease, Stroke, Heart Failure, and Mortality: A Cohort Study.Annals of internal medicine · 2015Trial
- The effects of weight loss and salt reduction on visit-to-visit blood pressure variability: results from a multicenter randomized controlled trial.Journal of hypertension · 2014Trial
- Relationships between metrics of visit-to-visit variability of blood pressure.Journal of human hypertension · 2013Trial
- Body Mass Index Variability and Cardiovascular Risk: Contemporary Evidence and Clinical Implications for Diabetes Care.Current diabetes reports · 2026Review
- Visit-to-Visit Variability in Lipid Levels and Risk of Incident Heart Failure in Adults With Type 2 Diabetes.Diabetes care · 2025Article
- Systemic Immune Inflammatory Index as Predictor of Blood Pressure Variability in Newly Diagnosed Hypertensive Adults Aged 18-75.Journal of clinical medicine · 2024Article
- The impact of different recovery positions on the perfusion of the lower forearm and comfort: A cross-over randomized controlled trial.Resuscitation plus · 2024Article
- Blood Pressure Variability and Risk of Atrial Fibrillation in Adults With Type 2 Diabetes.JACC. Advances · 2023Article
- Long-term fasting glucose variability and risk of cancer in patients with type 2 diabetes mellitus: A retrospective population-based cohort study in Shanghai.Journal of diabetes · 2022Article
- Body Weight Variability and Risk of Cardiovascular Outcomes and Death in the Context of Weight Loss Intervention Among Patients With Type 2 Diabetes.JAMA network open · 2022Article
- Variability of adiposity indices and incident heart failure among adults with type 2 diabetes.Cardiovascular diabetology · 2022Observational
- E-Selectin Is Associated with Daytime and 24-Hour Diastolic Blood Pressure Variability in Type 2 Diabetes.Biomedicines · 2022Article
- Blood pressure visit-to-visit variability and outcomes in patients with heart failure with preserved ejection fraction.ESC heart failure · 2021Article
- Long-Term Variability of Blood Pressure, Cardiovascular Outcomes, and Mortality: The Look AHEAD Study.American journal of hypertension · 2021Article
- Long-term variability of blood pressure and incidence of heart failure among individuals with Type 2 diabetes.ESC heart failure · 2021Article
- Predictive value of visit-to-visit blood pressure variability for cardiovascular events in patients with coronary artery disease with and without diabetes mellitus.Cardiovascular diabetology · 2021Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visit-to-visit variability (VVV) of blood pressure is associated with cardiovascular disease. The authors examined the effects of visit number and timing and automated or manual measurement device on VVV in the placebo arm of the Trial of Preventing Hypertension (TROPHY) (N=225) and simulations. VVV was assessed using intra-individual standard deviation (SD), range, maximum, coefficient of variation, successive variation, and average real variability of systolic blood pressure. VVV increased with number of visits used to calculate it in the TROPHY population (P for trend <.05 for all metrics) and simulations. Using consecutive visits in TROPHY, average SD was 5.6 mm Hg from 3 visits, 6.8 mm Hg from 7 visits, and 7.7 mm Hg from 18 visits. When 7 visits were spread out across 4 years, the average SD was higher (7.5 mm Hg) than when visits were consecutive over 18 months (P<.001). SD was higher using a single blood pressure measurement per visit (compared with the mean of 3 measurements per visit P<.001) and with automated vs manual devices (P<.001). In summary, number and timing of visits and device used to measure blood pressure influence VVV and need to be considered when designing, interpreting, and comparing studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.