ArticleInorganic chemistry2013
Discrete nanomolecular polyhedral borane scaffold supporting multiple gadolinium(III) complexes as a high performance MRI contrast agent.
Article in Inorganic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Post-Functionalization of Organometallic Complexes via Click-Reaction.Molecules (Basel, Switzerland) · 2022Article
- New type of RNA virus replication inhibitor based on decahydro-closo-decaborate anion containing amino acid ester pendant group.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Article
- Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin withMolecules (Basel, Switzerland) · 2022Article
- Amphiphilic DTPA Multimer Assembled on IcosahedralACS applied bio materials · 2021Article
- Synthesis of Bis(Carboranyl)amides 1,1'-μ-(CHMolecules (Basel, Switzerland) · 2021Article
- Boron Chemistry for Medical Applications.Molecules (Basel, Switzerland) · 2020Review
- Synthesis and Applications of Perfunctionalized Boron Clusters.Inorganic chemistry · 2018Article
- Validation and Comparison of the Therapeutic Efficacy of Boron Neutron Capture Therapy Mediated By Boron-Rich Liposomes in Multiple Murine Tumor Models.Translational oncology · 2017Article
- Advanced Functional Nanomaterials for Theranostics.Advanced functional materials · 2017Article
- Brightly Luminescent and Kinetically Inert Lanthanide Bioprobes Based on Linear and Preorganized Chelators.Bioconjugate chemistry · 2016Article
- Click Chemistry in the Development of Contrast Agents for Magnetic Resonance Imaging.Topics in magnetic resonance imaging : TMRI · 2016Review
- Gd(DOTAlaP): exploring the boundaries of fast water exchange in gadolinium-based magnetic resonance imaging contrast agents.Inorganic chemistry · 2014Article
- Lanthanide probes for bioresponsive imaging.Chemical reviews · 2014Review
- Synthesis and relaxivity studies of a DOTA-based nanomolecular chelator assembly supported by an icosahedral closo-B₁₂²⁻ core for MRI: a click chemistry approach.Molecules (Basel, Switzerland) · 2013Article
- cRGD peptide-conjugated icosahedral closo-B12(2-) core carrying multiple Gd3+-DOTA chelates for α(v)β3 integrin-targeted tumor imaging (MRI).Inorganic chemistry · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
An icosahedral closo-B(12)(2-) scaffold supports 12 copies of Gd(3+)-chelate held in close proximity with each other by suitable linkers which employ azide-alkyne click chemistry. This design is the first member of a new class of polyfunctional MRI contrast agents carrying a high payload of Gd(3+)-chelate in a sterically constrained configuration. The resulting contrast agent shows higher relaxivity values at high magnetic fields. MRI contrast agents currently in use are not as effective in this regard, presumably due to a lack of steric constraint of gadolinium centers and lower water exchange rates. In vivo MRI studies in mice show excellent contrast enhancement even at one-seventh of the safe clinical dose (0.04 mmol Gd/kg) for up to a 1 h exposure.
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Registered trials
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