ReviewBritish journal of clinical pharmacology2013
Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration.
Review in British journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Review
- Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease.Free radical biology & medicine · 2022Review
- Amyloid-β 25-35 Induces Neurotoxicity through the Up-Regulation of Astrocytic System XAntioxidants (Basel, Switzerland) · 2021Article
- Review of Design Considerations for Brain-on-a-Chip Models.Micromachines · 2021Review
- Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation.Cell death & disease · 2021Article
- Refocusing the Brain: New Approaches in Neuroprotection Against Ischemic Injury.Neurochemical research · 2021Review
- Nrf2-Mediated System xMolecular neurobiology · 2019Article
- Astrocytes and microglia: Models and tools.The Journal of experimental medicine · 2019Review
- Docosahexaenoic Acid (DHA) Inhibits FADS2 Expression in Astrocytes but Increases Survival of Neurons Co-cultured with DHA-enriched Astrocytes.International journal of molecular and cellular medicine · 2019Article
- NMDA receptor C-terminal signaling in development, plasticity, and disease.F1000Research · 2019Review
- Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress.Cell death and differentiation · 2018Article
- Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1Stem cell research & therapy · 2018Article
- Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory.Biochemical Society transactions · 2017Review
- Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes.Free radical biology & medicine · 2016Review
- Selective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neurons.Biochimica et biophysica acta · 2015Article
- Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.Nature communications · 2015Article
- Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system.Nature communications · 2015Article
- Systems approach to the study of brain damage in the very preterm newborn.Frontiers in systems neuroscience · 2015Article
- Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons.Psychopharmacology · 2014Article
- NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons.Neuroscience letters · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Glia, including astrocytes, are increasingly at the forefront of neurodegenerative research for their role in the modulation of neuronal function and survival. Improved understanding of underlying disease mechanisms, including the role of the cellular environment in neurodegeneration, is central to therapeutic development for these currently untreatable diseases. In these endeavours, experimental models that more closely reproduce the human condition have the potential to facilitate the transition between experimental studies in model organisms and patient trials. In this review we discuss the growing role of astrocytes in neurodegenerative diseases, and how astrocytes generated from human pluripotent stem cells represent a useful tool for analyzing astrocytic signalling and influence on neuronal function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.