Evidence map›Paper›PMID 23125917›Full record

ArticleJournal of parasitology research2012

Schistosoma tegument proteins in vaccine and diagnosis development: an update.

Cristina Toscano Fonseca, Gardênia Braz Figueiredo Carvalho, Clarice Carvalho Alves, Tatiane Teixeira de Melo

Open access · goldAbstract read
In one paragraph

Article in Journal of parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  6. HGPRT and PNP: Recombinant Enzymes fromPathogens (Basel, Switzerland) · 2023
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  9. Frontiers in immunology · 2022
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  10. Pathogens (Basel, Switzerland) · 2021
    Article
  11. Article
  12. A comprehensive and critical overview of schistosomiasis vaccine candidates.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021
    Review
  13. Article
  14. A Biological and Immunological Characterization ofInternational journal of molecular sciences · 2020
    Article
  15. Gene Expression in Developmental Stages ofInternational journal of molecular sciences · 2019
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  16. Comparative Genomic Analysis ofBioMed research international · 2019
    Article
  17. Article
  18. Article
  19. Metazoan Parasite Vaccines: Present Status and Future Prospects.Frontiers in cellular and infection microbiology · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cristina Toscano FonsecaLaboratório de Esquistossomose, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima 1715, Belo Horizonte,MG 30190-002, Brazil ; Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais (INCT-DT), Avenida Augusto de Lima 1715, Belo Horizonte, MG 30190-002, Brazil.
Gardênia Braz Figueiredo Carvalho
Clarice Carvalho Alves
Tatiane Teixeira de Melo
Fundação Oswaldo Cruz · BRInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of a vaccine against schistosomiasis and also the availability of a more sensitive diagnosis test are important tools to help chemotherapy in controlling disease transmission. Bioinformatics tools, together with the access to parasite genome, published recently, should help generate new knowledge on parasite biology and search for new vaccines or therapeutic targets and antigens to be used in the disease diagnosis. Parasite surface proteins, especially those expressed in schistosomula tegument, represent interesting targets to be used in vaccine formulations and in the diagnosis of early infections, since the tegument represents the interface between host and parasite and its molecules are responsible for essential functions to parasite survival. In this paper we will present the advances in the development of vaccines and diagnosis tests achieved with the use of the information from schistosome genome focused on parasite tegument as a source for antigens.

Identifiers

PMID23125917
PMCPMC3483795
OpenAlexW2079643260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.