ArticleFrontiers in computational neuroscience2012
An investigation of dendritic delay in octopus cells of the mammalian cochlear nucleus.
Article in Frontiers in computational neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- An anatomical and physiological basis for flexible coincidence detection in the auditory system.eLife · 2025Article
- A computational model of auditory chirp-velocity sensitivity and amplitude-modulation tuning in inferior colliculus neurons.Journal of computational neuroscience · 2024Article
- Enhanced Place Specificity of the Parallel Auditory Brainstem Response: An Electrophysiological Study.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Asymmetry in the Perception of Electrical Chirps Presented to Cochlear Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- A Computational Model of Auditory Chirp-Velocity Sensitivity and Amplitude-Modulation Tuning in Inferior Colliculus Neurons.Research square · 2024Article
- Enhanced Place Specificity of the Parallel Auditory Brainstem Response: An Electrophysiological Study.bioRxiv : the preprint server for biology · 2024Article
- Article
- Mammalian octopus cells are direction selective to frequency sweeps by excitatory synaptic sequence detection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A phenomenological spiking model for octopus cells in the posterior-ventral cochlear nucleus.Biological cybernetics · 2021Article
- Periodicity Pitch Perception.Frontiers in neuroscience · 2020Article
- A biophysical modelling platform of the cochlear nucleus and other auditory circuits: From channels to networks.Hearing research · 2018Article
- Modeling Pitch Perception With an Active Auditory Model Extended by Octopus Cells.Frontiers in neuroscience · 2018Article
- Dendritic and Axonal Propagation Delays May Shape Neuronal Networks With Plastic Synapses.Frontiers in physiology · 2018Review
- Compensation for Traveling Wave Delay Through Selection of Dendritic Delays Using Spike-Timing-Dependent Plasticity in a Model of the Auditory Brainstem.Frontiers in computational neuroscience · 2018Article
- Learning Pitch with STDP: A Computational Model of Place and Temporal Pitch Perception Using Spiking Neural Networks.PLoS computational biology · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Octopus cells, located in the mammalian auditory brainstem, receive their excitatory synaptic input exclusively from auditory nerve fibers (ANFs). They respond with accurately timed spikes but are broadly tuned for sound frequency. Since the representation of information in the auditory nerve is well understood, it is possible to pose a number of questions about the relationship between the intrinsic electrophysiology, dendritic morphology, synaptic connectivity, and the ultimate functional role of octopus cells in the brainstem. This study employed a multi-compartmental Hodgkin-Huxley model to determine whether dendritic delay in octopus cells improves synaptic input coincidence detection in octopus cells by compensating for the cochlear traveling wave delay. The propagation time of post-synaptic potentials from synapse to soma was investigated. We found that the total dendritic delay was approximately 0.275 ms. It was observed that low-threshold potassium channels in the dendrites reduce the amplitude dependence of the dendritic delay of post-synaptic potentials. As our hypothesis predicted, the model was most sensitive to acoustic onset events, such as the glottal pulses in speech when the synaptic inputs were arranged such that the model's dendritic delay compensated for the cochlear traveling wave delay across the ANFs. The range of sound frequency input from ANFs was also investigated. The results suggested that input to octopus cells is dominated by high frequency ANFs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.