ArticleSynlett : accounts and rapid communications in synthetic organic chemistry2012
Synthesis of Farnesol Analogues Containing Triazoles in Place of Isoprenes through 'Click Chemistry'
Article in Synlett : accounts and rapid communications in synthetic organic chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles.MedChemComm · 2017Article
- The Halogen Bond.Chemical reviews · 2016Review
- Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway.The Journal of biological chemistry · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
A solid-phase three-component Huisgen reaction has been used to generate polar farnesol and farnesyl diphosphate analogues. The Cu(I)-catalyzed 1,3-cycloadditions of various azides with solid supported (E)-3-methylhept-2-en-6-yn-1-ol provided only the 1,4-disubstituted 1,2,3-triazole regioisomers. The organic azides were generated in situ to minimize handling of potentially explosive azides. We have employed this powerful 'click chemistry' to make farnesol analogues where both β- and γ-isoprenes were replaced by triazole and substituted aromatic rings, respectively.
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Registered trials
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