ArticleEukaryotic cell2013
Molecular and morphological data support the existence of a sexual cycle in species of the genus Paracoccidioides.
Article in Eukaryotic cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Telomeric assemblies ofbioRxiv : the preprint server for biology · 2025Article
- Love in the time of climate change: A review of sexual reproduction in the order Onygenales.Fungal genetics and biology : FG & B · 2023Review
- Molecular Phylogenetic Analysis ofMicroorganisms · 2023Article
- Molecular epidemiology of Paracoccidiodes spp. recovered from patients with paracoccidioidomycosis in a teaching hospital from Minas Gerais State of Brazil.PLoS neglected tropical diseases · 2021Article
- Exploring genetic diversity, population structure, and phylogeography inStudies in mycology · 2021Article
- Updates inJournal of fungi (Basel, Switzerland) · 2021Review
- Paracoccidioimycosis and white individuals: Susceptibility and biogeographic aspects in an important endemic area in Brazil.PLoS neglected tropical diseases · 2021Article
- Identification of Potentially Therapeutic Immunogenic Peptides FromFrontiers in immunology · 2021Article
- Therapeutic Vaccination with Cationic Liposomes Formulated with Dioctadecyldimethylammonium and Trehalose Dibehenate (CAF01) and Peptide P10 Is Protective in Mice Infected withJournal of fungi (Basel, Switzerland) · 2020Article
- Mating type (MAT) locus and possible sexuality of the opportunistic pathogen Exophiala dermatitidis.Fungal genetics and biology : FG & B · 2019Article
- Species boundaries in the human pathogen Paracoccidioides.Fungal genetics and biology : FG & B · 2017Article
- Impact of Paracoccin Gene Silencing onmBio · 2017Article
- Paracoccidioides brasiliensis PS2: First Autochthonous Paracoccidioidomycosis Case Report in Rio de Janeiro, Brazil, and Literature Review.Mycopathologia · 2016Article
- PARACOCCIDIOIDOMYCOSIS: CHALLENGES IN THE DEVELOPMENT OF A VACCINE AGAINST AN ENDEMIC MYCOSIS IN THE AMERICAS.Revista do Instituto de Medicina Tropical de Sao Paulo · 2015Review
- Identification and characterization of expressed retrotransposons in the genome of the Paracoccidioides species complex.BMC genomics · 2015Article
- Asexual propagation of a virulent clone complex in a human and feline outbreak of sporotrichosis.Eukaryotic cell · 2015Article
- Proteomic profile response of Paracoccidioides lutzii to the antifungal argentilactone.Frontiers in microbiology · 2015Article
- Evolutionary Perspectives on Human Fungal Pathogens.Cold Spring Harbor perspectives in medicine · 2014Review
- Paracoccidioides species complex: ecology, phylogeny, sexual reproduction, and virulence.PLoS pathogens · 2014Article
- Fatal fungemia due to Paracoccidioides lutzii.The American journal of tropical medicine and hygiene · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genus Paracoccidioides includes the thermodimorphic species Paracoccidioides brasiliensis and P. lutzii, both of which are etiologic agents of paracoccidioidomycosis, a systemic mycosis that affects humans in Latin America. Despite the common occurrence of a sexual stage among closely related fungi, this has not been observed with Paracoccidioides species, which have thus been considered asexual. Molecular evolutionary studies revealed recombination events within isolated populations of the genus Paracoccidioides, suggesting the possible existence of a sexual cycle. Comparative genomic analysis of all dimorphic fungi and Saccharomyces cerevisiae demonstrated the presence of conserved genes involved in sexual reproduction, including those encoding mating regulators such as MAT, pheromone receptors, pheromone-processing enzymes, and mating signaling regulators. The expression of sex-related genes in the yeast and mycelial phases of both Paracoccidioides species was also detected by real-time PCR, with nearly all of these genes being expressed preferentially in the filamentous form of the pathogens. In addition, the expression of sex-related genes was responsive to the putative presence of pheromone in the supernatants obtained from previous cocultures of strains of two different mating types. In vitro crossing of isolates of different mating types, discriminated by phylogenetic analysis of the α-box (MAT1-1) and the high-mobility-group (HMG) domain (MAT1-2), led to the identification of the formation of young ascocarps with constricted coiled hyphae related to the initial stage of mating. These genomic and morphological analyses strongly support the existence of a sexual cycle in species of the genus Paracoccidioides.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.