ArticleChemical senses2013
Changes in the neural representation of odorants after olfactory deprivation in the adult mouse olfactory bulb.
Article in Chemical senses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Generalization of fear learning is shaped by inhibitory sensory processing in mice.Nature communications · 2026Article
- Environmental stress promotes the persistence of juvenile traits in olfactory neurons as a protective mechanism.iScience · 2025Article
- The influence of olfactory experience on the birthrates of olfactory sensory neurons with specific odorant receptor identities.Genesis (New York, N.Y. : 2000) · 2024Review
- The Role of the Stimulus in Olfactory Plasticity.Brain sciences · 2023Review
- Brief sensory deprivation triggers plasticity of dopamine-synthesising enzyme expression in genetically labelled olfactory bulb dopaminergic neurons.The European journal of neuroscience · 2022Article
- Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Congenital Cytomegalovirus Infection Alters Olfaction Before Hearing Deterioration In Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Stable olfactory sensory neuron in vivo physiology during normal aging.Neurobiology of aging · 2018Article
- Persistent, generalized hypersensitivity of olfactory bulb interneurons after olfactory fear generalization.Neurobiology of learning and memory · 2017Article
- Differences in peripheral sensory input to the olfactory bulb between male and female mice.Scientific reports · 2017Article
- Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice.Chemical senses · 2016Article
- Associative learning and sensory neuroplasticity: how does it happen and what is it good for?Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- A lateralized odor learning model in neonatal rats for dissecting neural circuitry underpinning memory formation.Journal of visualized experiments : JoVE · 2014Article
- Fear learning enhances neural responses to threat-predictive sensory stimuli.Science (New York, N.Y.) · 2013Article
- Presynaptic inhibition of olfactory sensory neurons: new mechanisms and potential functions.Chemical senses · 2013Review
- Odor-specific, olfactory marker protein-mediated sparsening of primary olfactory input to the brain after odor exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Spatiotemporal alterations in primary odorant representations in olfactory marker protein knockout mice.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Olfactory sensory deprivation during development has been shown to induce significant alterations in the neurophysiology of olfactory receptor neurons (ORNs), the primary sensory inputs to the brain's olfactory bulb. Deprivation has also been shown to alter the neurochemistry of the adult olfactory system, but the physiological consequences of these changes are poorly understood. Here we used in vivo synaptopHluorin (spH) imaging to visualize odorant-evoked neurotransmitter release from ORNs in adult transgenic mice that underwent 4 weeks of unilateral olfactory deprivation. Deprivation reduced odorant-evoked spH signals compared with sham-occluded mice. Unexpectedly, this reduction was equivalent between ORNs on the open and plugged sides. Changes in odorant selectivity of glomerular subpopulations of ORNs were also observed, but only in ORNs on the open side of deprived mice. These results suggest that naris occlusion in adult mice produces substantial changes in primary olfactory processing which may reflect not only the decrease in olfactory stimulation on the occluded side but also the alteration of response properties on the intact side. We also observed a modest effect of true sham occlusions that included noseplug insertion and removal, suggesting that conventional noseplug techniques may have physiological effects independent of deprivation per se and thus require more careful controls than has been previously appreciated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.