ArticleMolecular biology and evolution2013
LINE-1-derived poly(A) microsatellites undergo rapid shortening and create somatic and germline mosaicism in mice.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A complete human pancreatic cancer genome.bioRxiv : the preprint server for biology · 2026Article
- Direct identification ofbioRxiv : the preprint server for biology · 2025Article
- Somatic retrotransposition in the developing rhesus macaque brain.Genome research · 2022Article
- Higher Rates of Processed Pseudogene Acquisition in Humans and Three Great Apes Revealed by Long-Read Assemblies.Molecular biology and evolution · 2021Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals.PLoS genetics · 2019Article
- Heritable L1 retrotransposition in the mouse primordial germline and early embryo.Genome research · 2017Article
- Intact piRNA pathway prevents L1 mobilization in male meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Discovery of a new repeat family in the Callithrix jacchus genome.Genome research · 2016Article
- Article
- Distinct subcellular localization and potential role of LINE1-ORF1P in meiotic oocytes.Histochemistry and cell biology · 2016Article
- LINE-1 expression and retrotransposition in Barrett's esophagus and esophageal carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites.Genome research · 2015Article
- Article
- Genome-wide analysis of promoters: clustering by alignment and analysis of regular patterns.PloS one · 2014Article
- Non-LTR retrotransposons and microsatellites: Partners in genomic variation.Mobile genetic elements · 2013Review
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3 authors.
Funding
Abstract
Interspersed and tandem repeat sequences comprise the bulk of mammalian genomes. Interspersed repeats result from successive replication by transposable elements, such as Alu and long interspersed element type 1 (L1). Microsatellites are tandem repeats of 1-6 base pairs, among which poly(A) microsatellites are the most abundant in the human genome. The rise and fall of a microsatellite has been depicted as a life cycle. Previous studies have demonstrated that Alu and L1 insertions are a major source of A-rich microsatellites owing to the concurrent formation of a poly(A) DNA tract at the 3'-end of each insertion. The fate of such poly(A) tracts has been studied by surveying the length distribution of genomic resident Alu and L1 insertions. However, these cross-sectional studies provide no information about the tempo of mutation immediately after birth. In this study, de novo L1 insertions were created using a transgenic L1 mouse model and traced through generations to investigate the early life of poly(A) microsatellites. High frequencies of intra-individual and intergenerational shortening were observed for long poly(A) tracts, creating somatic and germline mosaicism at the insertion site, whereas little variation was observed for short poly(A) alleles. As poly(A) microsatellites are the major intrinsic signal for nucleosome positioning, their remarkable abundance and variability make them a significant source of epigenetic variation. Thus, the birth of poly(A) microsatellites from retrotransposons and the subsequent rapid and variable shortening represent a new way with which retrotransposons can modify the genetic and epigenetic architecture of our genome.
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