ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2013
Oxidative modification of the intestinal mucus layer is a critical but unrecognized component of trauma hemorrhagic shock-induced gut barrier failure.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Serine protease-driven entry and S2 ' cleavage flexibility of feline coronavirus during feline enterocyte infections.PLoS pathogens · 2026Article
- Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury.Digestive diseases and sciences · 2024Article
- Therapeutic Potential of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Prevention of Organ Injuries Induced by Traumatic Hemorrhagic Shock.Frontiers in immunology · 2021Review
- Cancer-protective effect of a synbiotic combination betweenGut microbes · 2020Article
- Canola meal in nursery pig diets: growth performance and gut health.Journal of animal science · 2020Article
- Effects of intestinal trefoil factor on intestinal mucus barrier in burned mice.American journal of translational research · 2020Article
- Metabolomics analysis of gut barrier dysfunction in a trauma-hemorrhagic shock rat model.Bioscience reports · 2019Article
- Effects of glutamine on intestinal mucus barrier after burn injury.American journal of translational research · 2018Article
- NK1.1Journal of leukocyte biology · 2017Article
- Resveratrol Improves Survival and Prolongs Life Following Hemorrhagic Shock.Molecular medicine (Cambridge, Mass.) · 2015Article
- Dissolution of lipids from mucus: a possible mechanism for prompt disruption of gut barrier function by alcohol.Toxicology letters · 2015Article
- Glutamine ameliorates intestinal ischemia-reperfusion Injury in rats by activating the Nrf2/Are signaling pathway.International journal of clinical and experimental pathology · 2015Article
- Intraluminal nonbacterial intestinal components control gut and lung injury after trauma hemorrhagic shock.Annals of surgery · 2014Article
- The intestinal mucus layer is a critical component of the gut barrier that is damaged during acute pancreatitis.Shock (Augusta, Ga.) · 2014Article
- Redefining the gut as the motor of critical illness.Trends in molecular medicine · 2014Review
- Article
- Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice.PloS one · 2014Article
- Low doses of celecoxib attenuate gut barrier failure during experimental peritonitis.Laboratory investigation; a journal of technical methods and pathology · 2013Article
- Intestinal barrier analysis by assessment of mucins, tight junctions, and α-defensins in healthy C57BL/6J and BALB/cJ mice.Tissue barriersArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies demonstrate that mechanisms underlying gut barrier failure include systemic processes and less studied luminal processes. We thus tested the hypothesis that mucus layer oxidation is a component of trauma/hemorrhagic shock-induced gut injury and dysfunction. Male Sprague-Dawley rats underwent trauma/hemorrhagic shock. Controls underwent trauma only. Mucus from the terminal 30 cm of the ileum was collected, processed, and analyzed for reactive nitrogen intermediates (RNI)-mediated damage, reactive oxygen species (ROS)-induced damage, and total antioxidant capacity. The distal ileum was stained to quantify the mucus layer; gut permeability was assessed physiologically. A time course study was conducted to determine the temporal sequence of mucus layer damage. The role of free radical-mediated damage to the gut barrier was investigated by the effect of the free radical scavenger dimethyl sulfoxide on trauma/hemorrhagic shock-induced changes on the mucus and on gut permeability. Trauma/hemorrhagic shock increased intestinal permeability, which was associated with evidence of loss of the unstirred mucus layer. These changes correlated with increased ROS- and RNI-mediated mucus damage and loss of mucus total antioxidant capacity. Based on the time course study, ROS-mediated mucus damage and loss of total antioxidant capacity were present immediately following shock, whereas RNI-mediated damage was delayed for 3 h. Dimethyl sulfoxide ameliorated gut barrier loss, ROS-mediated changes to the mucus layer, and loss of total antioxidant capacity. There was no change in RNI-induced changes to the mucus layer. These results support the hypothesis that trauma/hemorrhagic shock leads to mucus damage and gut dysfunction through the generation of free radical species.
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