ArticleJournal of biophotonics2014
Molecular photoacoustic tomography of breast cancer using receptor targeted magnetic iron oxide nanoparticles as contrast agents.
Article in Journal of biophotonics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Three-dimensional diffractive acoustic tomography.Nature communications · 2025Article
- From detection to elimination: iron-based nanomaterials driving tumor imaging and advanced therapies.Frontiers in oncology · 2025Review
- Visual inertial odometry enabled 3D ultrasound and photoacoustic imaging.Biomedical optics express · 2023Article
- Application of photoacoustic computed tomography in biomedical imaging: A literature review.Bioengineering & translational medicine · 2023Review
- Targeted contrast agents and activatable probes for photoacoustic imaging of cancer.Chemical Society reviews · 2022Review
- Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging.Nanomaterials (Basel, Switzerland) · 2022Review
- Introduction to Infrared and Raman-Based Biomedical Molecular Imaging and Comparison with Other Modalities.Molecules (Basel, Switzerland) · 2020Review
- Interactions Between Tumor Biology and Targeted Nanoplatforms for Imaging Applications.Advanced functional materials · 2020Article
- Black Mesoporous Silicon as a Contrast Agent for LED-Based 3D Photoacoustic Tomography.ACS applied materials & interfaces · 2020Article
- Listening to tissues with new light: recent technological advances in photoacoustic imaging.Journal of optics (2010) · 2019Article
- Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer.Chemical Society reviews · 2019Review
- Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope.Applied sciences (Basel, Switzerland) · 2017Article
- Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment.Molecular and clinical oncology · 2017Article
- Molecular Imaging in Nanotechnology and Theranostics.Molecular imaging and biology · 2017Review
- Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017Review
- In vivo deconvolution acoustic-resolution photoacoustic microscopy in three dimensions.Biomedical optics express · 2016Article
- Nanoparticle Probes for Structural and Functional Photoacoustic Molecular Tomography.BioMed research international · 2015Review
- Detection of cervical cancer based on photoacoustic imaging-the in-vitro results.Biomedical optics express · 2015Article
- Contrast agents for photoacoustic and thermoacoustic imaging: a review.International journal of molecular sciences · 2014Review
- Real-Time Nanoparticle-Cell Interactions in Physiological Media by Atomic Force Microscopy.ACS sustainable chemistry & engineering · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In this report, we present a breast imaging technique combining high-resolution near-infrared (NIR) light induced photoacoustic tomography (PAT) with NIR dye-labeled amino-terminal fragments of urokinase plasminogen activator receptor (uPAR) targeted magnetic iron oxide nanoparticles (NIR830-ATF-IONP) for breast cancer imaging using an orthotopic mouse mammary tumor model. We show that accumulation of the targeted nanoparticles in the tumor led to photoacoustic contrast enhancement due to the high absorption of iron oxide nanoparticles (IONP). NIR fluorescence images were used to validate specific delivery of NIR830-ATF-IONP to mouse mammary tumors. We found that systemic delivery of the targeted IONP produced 4- and 10-fold enhancement in photoacoustic signals in the tumor, compared to the tumor of the mice that received non-targeted IONP or control mice. The use of targeted nanoparticles allowed imaging of tumors located as deep as 3.1 cm beneath the normal tissues. Our study indicates the potential of the combination of photoacoustic tomography and receptor-targeted NIR830-ATF-IONP as a clinical tool that can provide improved specificity and sensitivity for breast cancer detection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.