ArticleJournal of Zhejiang University. Science. B2012
Propolis modulates vitronectin, laminin, and heparan sulfate/heparin expression during experimental burn healing.
Article in Journal of Zhejiang University. Science. B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Efficacy of topical heparin spray on donor site wound healing after split thickness skin grafting.Scientific reports · 2025Trial
- Effects of topical Turkish propolis on burn wound healing in an experimental burn model.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Electrospun PLGA-Propolis Scaffolds Regulate Collagen Architecture in Burn Wounds.International journal of molecular sciences · 2026Article
- Influence of Propolis-Containing Nonwoven PLGA Dressings on Dermatan and Chondroitin Sulfate Dynamics During Burn-Wound Healing.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The Effect of Topical Propolis Ointment on Severity of Episiotomy Pain and Wound Healing: A Triple-Blinded Randomized Controlled Clinical Trial.Journal of caring sciences · 2025Article
- The Role of Heparan Sulfate in Bone Repair and Regeneration.Calcified tissue international · 2025Review
- Propolis Stands out as a Multifaceted Natural Product: Meta-Analysis on Its Sources, Bioactivities, Applications, and Future Perspectives.Life (Basel, Switzerland) · 2025Review
- Mucus-derived biomaterial dressings: a novel approach to accelerate wound healing.Theranostics · 2025Review
- Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration.Periodontology 2000 · 2024Review
- Advancements in Skin Delivery of Natural Bioactive Products for Wound Management: A Brief Review of Two Decades.Pharmaceutics · 2022Review
- Research Progress on Therapeutic Effect and Mechanism of Propolis on Wound Healing.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Nonwoven Releasing Propolis as a Potential New Wound Healing Method-A Review.Molecules (Basel, Switzerland) · 2021Review
- Biodegradable Electrospun Nonwovens Releasing Propolis as a Promising Dressing Material for Burn Wound Treatment.Pharmaceutics · 2020Article
- The Estimation of Blood Paramagnetic Center Changes during Burns Management with Biodegradable Propolis-Nanofiber Dressing.Oxidative medicine and cellular longevity · 2020Article
- Topical TWEAK Accelerates Healing of Experimental Burn Wounds in Mice.Frontiers in pharmacology · 2018Article
- Sialylation of vitronectin regulates stress fiber formation and cell spreading of dermal fibroblasts via a heparin-binding site.Glycoconjugate journal · 2016Article
- Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound.Advances in wound care · 2016Review
- Influence of Temperature on Free Radical Generation in Propolis-Containing Ointments.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Bee Pollen as a Promising Agent in the Burn Wounds Treatment.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Diverse Roles of Heparan Sulfate and Heparin in Wound Repair.BioMed research international · 2015Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was aimed at assessing the dynamics of vitronectin (VN), laminin (LN), and heparan sulfate/heparin (HS/HP) content changes during experimental burn healing.
methodsVN, LN, and HS/HP were isolated and purified from normal and injured skin of domestic pigs, on the 3rd, 5th, 10th, 15th, and 21st days following thermal damage. The wounds were treated with apitherapeutic agent (propolis), silver sulfadiazine (SSD), physiological salt solution, and propolis vehicle. VN and LN were quantified using an immunoenzymatic assay and HS/HP was estimated by densitometric analysis.
resultsPropolis treatment stimulated significant increases in VN, LN, and HS/HP contents during the initial phase of study, followed by a reduction in the estimated extracellular matrix molecules. Similar patterns, although less extreme, were observed after treatment with SSD.
conclusionsThe beneficial effects of propolis on experimental wounds make it a potential apitherapeutic agent in topical burn management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.