ReviewCold Spring Harbor perspectives in biology2012
Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes.
Review in Cold Spring Harbor perspectives in biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 82 citations in OpenAlex.
- The transcription factor THAP11 is a general regulator of early embryonic polarization.bioRxiv : the preprint server for biology · 2026Article
- Epigenetic blind spots - the role of DNA methylation dynamics in stem cell-based models of embryogenesis.FEBS letters · 2026Article
- BMP4 and FGF2 promote heterogeneous priming including extraembryonic lineages in porcine expanded potential stem cells.Frontiers in cell and developmental biology · 2026Article
- Human stem cell-based embryo models: from self-organization to recapitulating development.Frontiers in cell and developmental biology · 2026Review
- GATAD2B is required for pre-implantation embryonic development by regulating zygotic genome activation.Cell proliferation · 2024Article
- scTOP: physics-inspired order parameters for cellular identification and visualization.Development (Cambridge, England) · 2023Article
- Generating human blastoids modeling blastocyst-stage embryos and implantation.Nature protocols · 2023Review
- scTOP: physics-inspired order parameters for cellular identification and visualization.bioRxiv : the preprint server for biology · 2023Article
- A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression.Development (Cambridge, England) · 2022Article
- Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm.Scientific reports · 2021Article
- Coordination between patterning and morphogenesis ensures robustness during mouse development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Regulation of stomatal development by stomatal lineage miRNAs.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Embryo competence and cryosurvival: Molecular and cellular features.Animal reproduction · 2019Article
- Re-evaluation of the causes of variation among mouse aggregation chimaeras.Biology open · 2019Article
- FGFR1 regulates trophectoderm development and facilitates blastocyst implantation.Developmental biology · 2019Article
- Single-cell RNA-sequencing reveals the existence of naive and primed pluripotency in pre-implantation rhesus monkey embryos.Genome research · 2018Article
- Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency.Developmental cell · 2017Article
- Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos.Genome research · 2017Article
- A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization.Developmental cell · 2016Article
- Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression.BMC biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of the three lineages of the mouse blastocyst provides a powerful model system to study interactions among cell behavior, cell signaling, and lineage development. Hippo signaling differences between the inner and outer cells of the early cleavage stages, combined with establishment of a stably polarized outer epithelium, lead to the establishment of the inner cell mass and the trophectoderm, whereas FGF signaling differences among the individual cells of the ICM lead to gradual separation and segregation of the epiblast and primitive endoderm lineages. Events in the late blastocyst lead to the formation of a special subset of cells from the primitive endoderm that are key sources for the signals that establish the subsequent body axis. The slow pace of mouse early development, the ability to culture embryos over this time period, the increasing availability of live cell imaging tools, and the ability to modify gene expression at will are providing increasing insights into the cell biology of early cell fate decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.