ArticleThe Journal of membrane biology2013
Presence of adrenergic receptors in rat endolymphatic sac epithelial cells.
Article in The Journal of membrane biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Expression and localization of αEuropean journal of histochemistry : EJH · 2023Article
- Ion transport its regulation in the endolymphatic sac: suggestions for clinical aspects of Meniere's disease.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Review
- βScientific reports · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intravenous application of catecholamines produces a depression in the endolymphatic sac direct current potential (ESP) and increases endolymphatic pressure via the β-adrenergic receptor (AR) in guinea pigs, suggesting that catecholamines play a role in the endolymphatic system. However, the localization of ARs in the endolymphatic sac (ES) is still undetermined. The presence of ARs in the rat ES was investigated by reverse transcriptase-polymerase chain reaction using laser capture microdissection (LCM) and immunohistochemical analysis. Expression of α(1A)-, α(1B)-, α(2A)-, α(2B)-, β(1)-, β(2)- and β(3)-ARs was observed in LCM samples of ES epithelia. Immunohistochemical analysis using specific antibodies showed immunofluorescence of β(2)- and β(3)-ARs in epithelial cells of the ES intermediate portion, and no specific staining results were obtained for α(1)-, α(2A)-, α(2B)- and β(1)-ARs. The presence of β(2)-AR with no clear immunostaining of β(1)-AR in ES epithelial cells is in accordance with previous electrophysiological and pharmacological results, which suggests that β(2)-AR mediates the action of catecholamines on the ESP. The presence of β(3)-AR in the ES epithelial cells and its absence in the stria vascularis implies that β(3)-AR plays a specific role in the ES.
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