ArticlePharmacoepidemiology and drug safety2013
Increasing use of atypical antipsychotics and anticonvulsants during pregnancy.
Article in Pharmacoepidemiology and drug safety, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Pregnancy and Delivery Outcomes Following Benzodiazepine Exposure: A Systematic Review and Meta-analysis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Pooled it
- Obstetric and neonatal outcomes after antipsychotic medication exposure in pregnancy.Obstetrics and gynecology · 2015Pooled it
- Lithium Use During Pregnancy in 14 Countries.JAMA network open · 2024Article
- General practitioner perceptions and experiences of managing perinatal mental health: a scoping review.BMC pregnancy and childbirth · 2023Article
- Antipsychotic utilization patterns in pregnant women with psychotic disorders: a 16-year population-based cohort study.European archives of psychiatry and clinical neuroscience · 2023Article
- The Patterns of Antipsychotic Use for Pregnant Women Over a 16-year Timeframe in an Australian Principal Referral and Specialist Women and Newborn Hospital.The Psychiatric quarterly · 2023Observational
- The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli.Journal of bacteriology · 2022Article
- Atypical antipsychotic use during pregnancy and birth defect risk: National Birth Defects Prevention Study, 1997-2011.Schizophrenia research · 2020Article
- Use of Prescribed Psychotropics during Pregnancy: A Systematic Review of Pregnancy, Neonatal, and Childhood Outcomes.Brain sciences · 2019Review
- Continuation of Atypical Antipsychotic Medication During Early Pregnancy and the Risk of Gestational Diabetes.The American journal of psychiatry · 2018Article
- Dosing and Monitoring: Children and Adolescents.Psychopharmacology bulletin · 2018Review
- Psychotropic Drug Use before, during, and after Pregnancy: A Population-Based Study in a Canadian Cohort (2001-2013).Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Article
- Prenatal exposure to antipsychotic medication and use of primary health care system in childhood: a population-based cohort study in Denmark.Clinical epidemiology · 2017Article
- Neonatal Adaptation Issues After Maternal Exposure to Prescription Drugs: Withdrawal Syndromes and Residual Pharmacological Effects.Drug safety · 2016Review
- Article
- Treatment of bipolar disorders during pregnancy: maternal and fetal safety and challenges.Drug, healthcare and patient safety · 2015Review
- Patterns of prescription of antidepressants and antipsychotics across and within pregnancies in a population-based UK cohort.Maternal and child health journal · 2014Article
- Competent psychopharmacology.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2014Review
- Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries.Archives of women's mental health · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo quantify maternal use of atypical antipsychotics, typical antipsychotics, anticonvulsants, and lithium during pregnancy.
methodsTennessee birth and death records were linked to Tennessee Medicaid data to conduct a retrospective cohort study of 296,817 women enrolled in Tennessee Medicaid throughout pregnancy who had a live birth or fetal death from 1985 to 2005.
resultsDuring the study time period, the adjusted rate of use of any study medication during pregnancy increased from nearly 14 to 31 per 1000 pregnancies (β = 0.08, 95% CI = 0.07, 0.09). Significant increases were reported in use of anticonvulsants alone among mothers with pain and other psychiatric disorders, atypical antipsychotics alone among mothers with bipolar disorders, schizophrenia, unipolar depressive disorders, and other psychiatric disorders, and more than one studied medication for mothers with epilepsy, pain disorders, bipolar disorders, unipolar depressive disorders, and other psychiatric disorders. Significant decreases were reported in use of lithium alone and typical antipsychotics alone for all clinically meaningful diagnosis groups.
conclusionsThere was a substantial increase in use of atypical antipsychotics alone, anticonvulsants alone, and medications from multiple studied categories among Tennessee Medicaid-insured pregnant women during the study period. Further examination of the maternal and fetal consequences of exposure to these medications during pregnancy is warranted.
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