Evidence map›Paper›PMID 23124783›Full record

Trial reportClinical journal of the American Society of Nephrology : CJASN2013

Effect of hemodiafiltration on quality of life over time.

Albert H A Mazairac, G Ardine de Wit, Muriel P C Grooteman, E Lars Penne, Neelke C van der Weerd, Claire H den Hoedt, Renée Lévesque, Marinus A van den Dorpel, Menso J Nubé, Piet M ter Wee and 3 more

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical journal of the American Society of Nephrology : CJASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Effect of online hemodiafiltration on quality of life, fatigue and recovery time: a systematic review and meta-analysis.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
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  11. CONVINCE in the context of existing evidence on haemodiafiltration.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Albert H A MazairacDepartment of Nephrology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
G Ardine de Wit
Muriel P C Grooteman
E Lars Penne
Neelke C van der Weerd
Claire H den Hoedt
Renée Lévesque
Marinus A van den Dorpel
Menso J Nubé
Piet M ter Wee
Michiel L Bots
Peter J Blankestijn
CONTRAST Investigators
Vrije Universiteit Amsterdam · NLAmsterdam UMC Location VUmc · NLMaasstad Ziekenhuis · NLUniversity Medical Center Utrecht · NLHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesIt is unclear if hemodiafiltration leads to a better quality of life compared with hemodialysis. It was, therefore, the aim of this study to assess the effect of hemodiafiltration on quality of life compared with hemodialysis in patients with ESRD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study analyzed the data of 714 patients with a median follow-up of 2 years from the Convective Transport Study. The patients were enrolled between June of 2004 and December of 2009. The Convective Transport Study is a randomized controlled trial on the effect of online hemodiafiltration versus low-flux hemodialysis on all-cause mortality. Quality of life was assessed with the Kidney Disease Quality of Life-Short Form. This questionnaire provides data for a physical and mental composite score and describes kidney disease-specific quality of life in 12 domains. The domains have scales from 0 to 100.

resultsThere were no significant differences in changes in health-related quality of life over time between patients treated with hemodialysis (n=358) or hemodiafiltration (n=356). The quality of life domain patient satisfaction declined over time in both dialysis modalities (hemodialysis: -2.5/yr, -3.4 to -1.5, P<0.001; hemodiafiltration: -1.4/yr, -2.4 to -0.5, P=0.004).

conclusionsCompared with hemodialysis, hemodiafiltration had no significant effect on quality of life over time.

Indexed as

Quality of LifeAgedFemaleFollow-Up StudiesHemodiafiltrationHumansKidney Failure, ChronicMaleMiddle AgedRenal DialysisSurveys and QuestionnairesTreatment Outcome

Identifiers

PMID23124783
PMCPMC3531648
OpenAlexW2165464931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.