Trial reportAJNR. American journal of neuroradiology2013
Anatomic MR imaging and functional diffusion tensor imaging of peripheral nerve tumors and tumorlike conditions.
Trial report in AJNR. American journal of neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- Current whole-body MRI applications in the neurofibromatoses: NF1, NF2, and schwannomatosis.Neurology · 2016Guideline
- Neurolymphomatosis: A Comprehensive Review of Clinical and Imaging Features.Radiology. Imaging cancer · 2026Review
- Article
- Whole-Body Magnetic Resonance Neurography-Technique, Current Perspectives, and Future Directions.Magnetic resonance imaging clinics of North America · 2025Review
- Review
- Advanced Imaging of the Peripheral Nerves, From theAJR. American journal of roentgenology · 2024Review
- Contrast-enhanced magnetic resonance neurography for diagnosing brachial plexopathy: improved visualization and additional imaging features.Scientific reports · 2024Article
- Diffusion Tensor Imaging in Determining Atypical Peripheral Nerve Neuroma in a Patient with a Painless Mass.The Eurasian journal of medicine · 2024Article
- Ulnar neuropathy at the elbow: associations of pre-operative DTI parameters with clinical outcomes after cubital tunnel decompression.European radiology · 2023Article
- The Temporary Mental Nerve Paresthesia as an Outcome of Dentigerous Cyst Removal during Preparation for Dental Implant Placement: A Case Report.Medicina (Kaunas, Lithuania) · 2023Article
- Correlation between diffusion tensor indices and fascicular morphometric parameters of peripheral nerve.Frontiers in physiology · 2023Article
- Schwannomas mistaken for metastases of melanoma in PET-CT: A diagnostic challenge with consequences.Clinical case reports · 2022Article
- Diffusion Tensor Imaging of a Median Nerve by Magnetic Resonance: A Pilot Study.Life (Basel, Switzerland) · 2022Article
- New insights into the evaluation of peripheral nerves lesions: a survival guide for beginners.Neuroradiology · 2022Review
- Role of diffusion tensor imaging in the evaluation of ulnar nerve involvement in leprosy.The British journal of radiology · 2022Article
- Case report: A quantitative and qualitative diffusion tensor imaging (DTI) study in varicella zoster-related brachial plexopathy.Frontiers in neuroimaging · 2022Article
- Virtual Biopsy in Soft Tissue Sarcoma. How Close Are We?Frontiers in oncology · 2022Review
- Imaging of traumatic peripheral nerve injuries.Journal of clinical orthopaedics and trauma · 2021Article
- Morphology of the entering and exiting nerve as a differentiating feature of benign from malignant peripheral nerve sheath tumours of the brachial plexus.Skeletal radiology · 2021Article
- An update in musculoskeletal tumors: from quantitative imaging to radiomics.La Radiologia medica · 2021Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeA number of benign and malignant peripheral nerve tumor and tumorlike conditions produce similar imaging features on conventional anatomic MR imaging. Functional MR imaging using DTI can increment the diagnostic performance in differentiation of these lesions. Our aim was to evaluate the role of 3T anatomic MR imaging and DTI in the characterization of peripheral nerve tumor and tumorlike conditions. MATERIALS AND
methodsTwenty-nine patients (13 men, 16 women; mean age, 41±18 years; range, 11-83 years) with a nerve tumor or tumorlike condition (25 benign, 5 malignant) underwent 3T MR imaging by using anatomic (n=29), functional diffusion, DWI (n=21), and DTI (n=24) techniques. Images were evaluated for image quality (3-point scale), ADC of the lesion, tractography, and fractional anisotropy of nerves with interobserver reliability in ADC and FA measurements.
resultsNo significant differences were observed in age (benign, 40±18 versus malignant, 45±19 years) and sex (benign, male/female=12:12 versus malignant, male/female=3:2) (P>.05). All anatomic (29/29, 100%) MR imaging studies received "good" quality; 20/21 (95%) DWI and 21/24 (79%) DTI studies received "good" quality. ADC of benign lesions (1.848±0.40×10(-3) mm2/s) differed from that of malignant lesions (0.900±0.25×10(-3) mm2/s, P<.001) with excellent interobserver reliability (ICC=0.988 [95% CI, 0.976-0.994]). There were no FA or ADC differences between men and women (P>.05). FA of involved nerves was lower than that in contralateral healthy nerves (P<.001) with excellent interobserver reliability (ICC=0.970 [95% CI, 0.946-0.991]). ADC on DTI and DWI was not statistically different (P>.05), with excellent intermethod reliability (ICC=0.943 [95% CI, 0.836-0.980]). Tractography differences were observed in benign and malignant lesions.
conclusions3T MR imaging and DTI are valuable methods for anatomic and functional evaluation of peripheral nerve lesions with excellent interobserver reliability. While tractography and low FA provide insight into neural integrity, low diffusivity values indicate malignancy in neural masses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.