ArticleCell biology international reports2012
hMSCs possess the potential to differentiate into DP cells in vivo and in vitro.
Article in Cell biology international reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Isolation, characterization and differentiation of dermal papilla cells from Small-tail Han sheep.Animal biotechnology · 2023Article
- Scalable and high-throughput production of an injectable platelet-rich plasma (PRP)/cell-laden microcarrier/hydrogel composite system for hair follicle tissue engineering.Journal of nanobiotechnology · 2022Article
- Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules.International journal of molecular sciences · 2022Article
- Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle.Stem cell research & therapy · 2021Article
- Amphiregulin promotes hair regeneration of skin-derived precursors via the PI3K and MAPK pathways.Cell proliferation · 2021Article
- The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits.BMC developmental biology · 2020Article
- Wnt10b promotes hair follicles growth and dermal papilla cells proliferation via Wnt/β-Catenin signaling pathway in Rex rabbits.Bioscience reports · 2020Article
- Therapeutic Potential of Stem Cells in Follicle Regeneration.Stem cells international · 2018Review
- Mesenchymal stem cells with modification of junctional adhesion molecule a induce hair formation.Stem cells translational medicine · 2014Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DP (dermal papilla) is a mesenchyme-derived structure situated at the base of the HF (hair follicle) that plays an important role in embryonic hair morphogenesis and maintenance of the hair growth cycle. hMSCs (human mesenchymal stem cells) have gained widespread attention in the field of tissue engineering, but not much is known about the differentiation of hMSCs into DP cells. hMSCs involved in HF formation were examined in our previous study. Here, we have explored the differentiation potential of hMSCs into DP cells by co-culturing hMSCs with DP cells, which proved to be the case. During the differentiation process, the expression of versican, CD133, SCF (stem cell factor), ET-1 (endothelin-1) and bFGF (basic fibroblast growth factor) increased. Compared with hMSCs alone, the aggregate number clearly increased when co-cultured with DP cells. The expression in vivo of HLA-I (human leucocyte antigen class I) was confined to DP of the newly formed HF. The data suggest that hMSCs possess the potential to differentiate into DP cells in vivo and in vitro.
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