ArticleJournal of gastroenterology2013
The relationship between transient elastography and histological collagen proportionate area for assessing fibrosis in chronic viral hepatitis.
Article in Journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- AI Digital Pathology Using qFibrosis Shows Heterogeneity of Fibrosis Regression in Patients with Chronic Hepatitis B and C with Viral Response.Diagnostics (Basel, Switzerland) · 2024Article
- Staging Liver Fibrosis by Fibroblast Activation Protein Inhibitor PET in a Human-Sized Swine Model.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Portal hypertension is the main driver of liver stiffness in advanced liver cirrhosis.Physiological research · 2021Article
- Automated quantification and architectural pattern detection of hepatic fibrosis in NAFLD.Annals of diagnostic pathology · 2020Article
- Sinusoidal and pericellular fibrosis in adult post-transplant liver biopsies: association with hepatic stellate cell activation and patient outcome.Virchows Archiv : an international journal of pathology · 2019Article
- Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring.Transplantation · 2019Review
- Comparison of collagen proportionate areas in liver fibrosis quantification between chronic hepatitis B and C.Medicine · 2016Observational
- Primary biliary cirrhosis degree assessment by acoustic radiation force impulse imaging and hepatic fibrosis indicators.World journal of gastroenterology · 2016Observational
- Prospective comparison of magnetic resonance imaging to transient elastography and serum markers for liver fibrosis detection.Liver international : official journal of the International Association for the Study of the Liver · 2016Article
- Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness.World journal of gastroenterology · 2016Review
- Evaluation of Histological and non-Invasive Methods for the Detection of Liver Fibrosis: The Values of Histological and Digital Morphometric Analysis, Liver Stiffness Measurement and APRI Score.Pathology oncology research : POR · 2016Article
- Normal and Fibrotic Rat Livers Demonstrate Shear Strain Softening and Compression Stiffening: A Model for Soft Tissue Mechanics.PloS one · 2016Article
- Current strategies for quantitating fibrosis in liver biopsy.Chinese medical journal · 2015Review
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- Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C.World journal of gastroenterology · 2014Article
- Recurrence of hepatitis C after liver transplantation.Annals of gastroenterology · 2013Review
- Evaluation of liver fibrosis: "Something old, something new…".Annals of gastroenterologyReview
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCollagen proportionate area (CPA) has a better correlation with hepatic venous pressure gradient (HVPG) than with Ishak stage. Liver stiffness measurement (LSM) is proposed as non invasive marker of portal hypertension/disease progression. Our aim was to compare LSM and CPA with Ishak staging in chronic viral hepatitis, and HVPG in HCV hepatitis after transplantation.
methodsOne hundred and sixty-nine consecutive patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections pre/post liver transplantation (LT), had a liver biopsy combined with LSM (transient elastography), CPA (biopsies stained with Sirius Red and evaluated by digital image analysis and expressed as CPA) and HVPG (measured contemporaneously with transjugular biopsies in LT HCV patients).
resultsLSM was dependent on CPA in HBV (r (2) = 0.61, p < 0.0001), HCV (r (2) = 0.59, p < 0.0001) and LT groups (r (2) = 0.64, p < 0.0001). In all three groups, CPA and Ishak were predictors of LSM, but multivariately CPA was better related to LSM (HBV: r (2) = 0.61, p < 0.0001; HCV: r (2) = 0.59, p < 0.0001; post-LT: r (2) = 0.68, p < 0.0001) than Ishak stage. In the LT group, multiple regression analysis including HVPG, LSM, aspartate aminotransferase to platelet ratio index (APRI) and Ishak stage/grade, showed that only CPA was related to HVPG (r (2) = 0.41, p = 0.01), both for HVPG ≥6 mmHg (OR 1.34, 95 % CI 1.14-1.58; p < 0.0001) or ≥10 mmHg (OR 1.25, 95 % CI 1.06-1.47; p = 0.007).
conclusionCPA was related to LSM in HBV or HCV hepatitis pre/post-LT. CPA was better related to LSM than Ishak stage. In the LT HCV group, CPA was better related to HVPG than Ishak stage/grade, LSM or APRI. CPA may represent a better comparative histological index for LSM, rather than histological stages.
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