ArticleClinical & experimental metastasis2013
Tumor location and nature of lymphatic vessels are key determinants of cancer metastasis.
Article in Clinical & experimental metastasis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Lymphatic Vessel Density or Area Are Not Reliable Prognostic Factors in Oral Cancer.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Article
- A preoperative prediction model for ipsilateral axillary lymph node metastasis of breast cancer based on clinicopathological and ultrasonography features: a prospective cohort study.Frontiers in oncology · 2025Article
- Effects of intravenous chemotherapy after TURBT for high-risk nonmuscle invasive bladder cancer: results of a retrospective study.Journal of cancer research and clinical oncology · 2023Article
- Lymphatic vasculature in ovarian cancer.Biochimica et biophysica acta. Reviews on cancer · 2023Review
- Establishment of risk prediction nomogram for ipsilateral axillary lymph node metastasis in T1 breast cancer.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021Article
- Risk factors for axillary lymph node metastases in clinical stage T1-2N0M0 breast cancer patients.Medicine · 2019Observational
- Protective role of JNK inhibitor SP600125 in sepsis-induced acute lung injury.International journal of clinical and experimental pathology · 2019Article
- Docetaxel facilitates lymphatic-tumor crosstalk to promote lymphangiogenesis and cancer progression.BMC cancer · 2018Article
- Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology.Scientific data · 2017Article
- The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment.Frontiers in immunology · 2016Review
- Dissemination via the lymphatic or angiogenic route impacts the pathology, microenvironment and hypoxia-related drug response of lung metastases.Clinical & experimental metastasis · 2015Article
- Lymphangiogenesis and lymphatic vessel remodelling in cancer.Nature reviews. Cancer · 2014Review
- Clinicopathology significance of podoplanin immunoreactivity in esophageal squamous cell carcinoma.International journal of clinical and experimental pathology · 2014Article
- Generation of homologous cell pairs using the oral lymphatic system.International journal of clinical and experimental pathology · 2014Article
- Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis.Clinical & experimental metastasis · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor metastasis to lymph nodes is a key indicator of patient survival, and is enhanced by the neo-lymphatics induced by tumor-secreted VEGF-C or VEGF-D, acting via VEGFR-3 signalling. These targets constitute important avenues for anti-metastatic treatment. Despite this new understanding, clinical observations linking metastasis with tumor depth or location suggest that lymphangiogenic growth factors are not the sole determinants of metastasis. Here we explored the influence of tumor proximity to lymphatics capable of responding to growth factors on nodal metastasis in a murine VEGF-D over-expression tumor model. We found that primary tumor location profoundly influenced VEGF-D-mediated lymph node metastasis: 89 % of tumors associated with the flank skin metastasised, in contrast with only 19 % of tumors located more deeply on the body wall (p < 0.01). Lymphatics in metastatic tumors arose from small lymphatics, and displayed distinct molecular and morphological profiles compared with those found in normal lymphatics. Smaller lymphatic subtypes were more abundant in skin (2.5-fold, p < 0.01) than in body wall, providing a richer source of lymphatics for VEGF-D(+) skin tumors, a phenomenon also confirmed in human samples. This study shows that the proximity of a VEGF-D(+) primary tumor to small lymphatics is an important determinant of metastasis. These observations may explain why tumor location relative to the lymphatic network is prognostically important for some human cancers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.