ArticleMolecules (Basel, Switzerland)2012
A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides.Molecules (Basel, Switzerland) · 2021Review
- Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses.Molecules (Basel, Switzerland) · 2021Review
- Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex.Pharmaceutics · 2020Article
- New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with CaMarine drugs · 2019Article
- Antioxidant, Antidiabetic, and Anticholinesterase Activities and Phytochemical Profile ofPlants (Basel, Switzerland) · 2019Article
- Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs.Marine drugs · 2018Article
- Crystal structure ofActa crystallographica. Section E, Crystallographic communications · 2018Article
- Crystal structure of an ep-oxy-sterol: 9α,11α-ep-oxy-5α-cholest-7-ene-3β,5,6α-triol 3,6-di-acetate.Acta crystallographica. Section E, Crystallographic communications · 2017Article
- Pseudosymmetry and highActa crystallographica. Section E, Crystallographic communications · 2017Article
- Crystal structure of a new spiro-polytetra-hydro-furan compound with translational pseudosymmetry:Acta crystallographica. Section E, Crystallographic communications · 2017Article
- 5-Amino-1-(2',3'-Acta crystallographica. Section E, Crystallographic communications · 2017Article
- Synthesis of cyclic N (1)-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells.Beilstein journal of organic chemistry · 2015Article
- Synthesis and pharmacological evaluation of modified adenosines joined to mono-functional platinum moieties.Molecules (Basel, Switzerland) · 2014Article
- Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.Molecules (Basel, Switzerland) · 2013Article
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Authors and funding
8 authors.
Funding
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Abstract
The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR), a strict analogue of AICAR that cannot be 5'-phosphorylated to ZMP by cellular kinases, is reported.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.