ArticleNeurochemical research2013
The expression patterns of MHC class I molecules in the developmental human visual system.
Article in Neurochemical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Development of a humanized HLA-A30 transgenic mouse model.Animal models and experimental medicine · 2022Article
- Competency of iPSC-derived retinas in MHC-mismatched transplantation in non-human primates.Stem cell reports · 2022Article
- Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders.Frontiers in genome editing · 2020Review
- MiR34a Regulates Neuronal MHC Class I Molecules and Promotes Primary Hippocampal Neuron Dendritic Growth and Branching.Frontiers in cellular neuroscience · 2020Article
- Article
- Retrograde interferon-gamma signaling induces major histocompatibility class I expression in human-induced pluripotent stem cell-derived neurons.Annals of clinical and translational neurology · 2018Article
- CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Expression and alternative splicing of classical and nonclassical MHCI genes in the hippocampus and neuromuscular junction.Molecular and cellular neurosciences · 2016Article
- Developmental expression and localization of MHC class I molecules in the human central nervous system.Experimental brain research · 2015Article
- Spatial-Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain.Neurochemical research · 2015Article
- Article
- MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration.Nature communications · 2014Article
- The similar expression pattern of MHC class I molecules in human and mouse cerebellar cortex.Neurochemical research · 2014Article
- Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson's and other brain diseases.Frontiers in neuroanatomy · 2014Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been considered that healthy neurons in central nervous system (CNS) do not express major histocompatibility complex (MHC) class I molecules. However, recent studies clearly demonstrated the expression of functional MHC class I in the mammalian embryonic, neonatal and adult brain. Until now, it is still unknown whether MHC I molecules are expressed in the development of human brain. We collected nine human brain tissues from fetuses aged from 21 to 31 gestational weeks (GW), one newborn of postnatal 55 days and one adult. The expression of MHC class I molecules was detected during the development of visual system in human brain by immunohistochemistry and immunofluorescence. MHC class I proteins were located at lateral geniculate nucleus (LGN) and the expression was gradually increased from 21 GW to 31 GW and reached high levels at 30-31 GW when fine-scale refinement phase was mediated by neural electric activity. However, there was no expression of MHC class I molecules in the visual cortical cortex during all the developmental stages examined. We also concluded that MHC class I molecules were mainly expressed in neurons but not in astrocytes at LGN. In the developing visual system, the expression of β2M protein on neurons was not found in our study.
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