ReviewUrological research2012
Biomolecular mechanism of urinary stone formation involving osteopontin.
Review in Urological research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04695951 (Efficacy and Safety of Renalof® in the Removal of Calculi Smaller Than 10 mm Located in the Reno-Ureteral Tract), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Renalof® in the Removal of Calculi Smaller Than 10 mm Located in the Reno-Ureteral Tract
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Smoking and Risk of Urolithiasis: Meta-Analysis of Observational Studies.Frontiers in public health · 2022Pooled it
- Article
- Intercalated bacterial biofilms are intrinsic internal components of calcium-based kidney stones.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The role of osteopontin in modulating macrophage phagocytosis of calcium oxalate crystals.Urolithiasis · 2025Article
- Study protocol for a randomized single-center cross-over study: Dapagliflozin treatment in recurring kidney stone patients.PloS one · 2025Article
- Bioinformatics identifies key genes and potential therapeutic targets in the pathological mechanism of oxidative stress in Randall's plaque.Scientific reports · 2024Article
- Prolyl hydroxylase domain inhibitors prevent kidney crystal formation by suppressing inflammation.Urolithiasis · 2024Article
- Suppression of renal crystal formation, inflammation, and fibrosis by blocking oncostatin M receptor β signaling.Scientific reports · 2024Article
- Urinary Stone Composition Analysis of 1465 Patients: The First Series from Azerbaijan.Archives of Iranian medicine · 2024Article
- SGLT2 Inhibitors and Their Effect on Urolithiasis: Current Evidence and Future Directions.Journal of clinical medicine · 2024Review
- A missense mutant of ocrl1 promotes apoptosis of tubular epithelial cells and disrupts endocytosis and the cell cycle of podocytes in Dent-2 Disease.Cell communication and signaling : CCS · 2023Article
- Oxalate homeostasis.Nature reviews. Nephrology · 2023Review
- Multicolor imaging of calcium-binding proteins in human kidney stones for elucidating the effects of proteins on crystal growth.Scientific reports · 2021Article
- Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation.Nature reviews. Nephrology · 2021Review
- Essential roles of oncostatin M receptor β signaling in renal crystal formation in mice.Scientific reports · 2020Article
- Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.Autophagy · 2020Article
- Article
- Sialometric and Sialochemical Analysis in Individuals With Pulp Stones.Frontiers in cell and developmental biology · 2020Article
- Mitochondrial Dysfunction and Kidney Stone Disease.Frontiers in physiology · 2020Review
- Osteoclasts secrete osteopontin into resorption lacunae during bone resorption.Histochemistry and cell biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary stones consist of two phases-an inorganic (mineral) phase and an organic (matrix) phase. Studies on the organic components of kidney stones have been undertaken later than those on the inorganic components. After osteopontin was identified as one of the matrix components, the biomolecular mechanism of urinary stone formation became clearer. It also triggered the development of new preventive treatments. Osteopontin expression is sporadically observed in normal distal tubular cells and is markedly increased in stone-forming kidneys. Calcium oxalate crystals adhering to renal tubular cells are incorporated into cells by the involvement of osteopontin. Stimulation of crystal-cell adhesion impairs the opening of mitochondrial permeability transition pores (mPTP) in tubular cells and produces oxidative stress, apoptosis, and osteopontin expression. Macrophages phagocytose and digest a small amount of crystals, but many crystals aggregate into a mass containing osteopontin and epithelial cell debris and are excreted into the renal tubular lumen, becoming nuclei of urinary stones. This biomolecular mechanism is similar to atherosclerotic calcification. Based on these findings, new preventive treatments have been developed. Dietary control such as low-cholesterol intake and the ingestion of antioxidative foods and vegetables have successfully reduced the 5-year recurrence rate. Osteopontin antibodies and cyclosporine A, which blocks the opening of mPTP, have markedly inhibited the expression of osteopontin and urinary stone formation in animal models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.