ArticleJournal of biomedical optics2012
Photoacoustic tomography through a whole adult human skull with a photon recycler.
Article in Journal of biomedical optics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Pulsed laser diode excitation for transcranial photoacoustics.Biomedical optics express · 2025Article
- A Deep Learning-Based Approach to Characterize Skull Physical Properties: A Phantom Study.Journal of biophotonics · 2025Article
- Ultrasound-assisted aberration correction of transcranial photoacoustic imaging based on angular spectrum theory.Photoacoustics · 2024Article
- Dual-modal Photoacoustic and Ultrasound Imaging: from preclinical to clinical applications.Frontiers in photonics · 2024Article
- Deep learning on photoacoustic tomography to remove image distortion due to inaccurate measurement of the scanning radius.Biomedical optics express · 2023Article
- A frequency-domain model-based reconstruction method for transcranial photoacoustic imaging: A 2D numerical investigation.Photoacoustics · 2023Article
- Photoacoustic Microscopic Imaging of Cerebral Vessels for Intensive Monitoring of Metabolic Acidosis.Molecular imaging and biology · 2023Article
- Photoacoustic digital brain and deep-learning-assisted image reconstruction.Photoacoustics · 2023Article
- Optical Light Sources and Wavelengths within the Visible and Near-Infrared Range Using Photoacoustic Effects for Biomedical Applications.Biosensors · 2022Review
- Multiscale photoacoustic tomography of neural activities with GCaMP calcium indicators.Journal of biomedical optics · 2022Article
- Multimodal Noninvasive Functional Neurophotonic Imaging of Murine Brain-Wide Sensory Responses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Massively parallel functional photoacoustic computed tomography of the human brain.Nature biomedical engineering · 2022Article
- Photoacoustic Imaging in Biomedicine and Life Sciences.Life (Basel, Switzerland) · 2022Review
- Photoacoustic imaging of squirrel monkey cortical and subcortical brain regions during peripheral electrical stimulation.Photoacoustics · 2022Article
- Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal pigletsJournal of neural engineering · 2022Article
- Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.Frontiers in neuroscience · 2022Review
- Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics.Frontiers in medicine · 2022Review
- Photoacoustic imaging for monitoring of stroke diseases: A review.Photoacoustics · 2021Review
- Photoacoustic computed tomography for functional human brain imaging [Invited].Biomedical optics express · 2021Review
- High Resolution, Deep Imaging Using Confocal Time-of-Flight Diffuse Optical Tomography.IEEE transactions on pattern analysis and machine intelligence · 2021Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
ABSTRACT. Photoacoustic tomography (PAT) of the human brain is challenging due to the fact that the skull strongly absorbs and scatters light, and attenuates and distorts ultrasound as well. For the first time, we demonstrated the feasibility of PAT through a whole adult human skull. A photon recycler (PR) was built to increase light transmittance through the skull. Both a graphite target and a canine brain were imaged through the skull. Use of the PR was found to improve the photoacoustic signal-to-noise ratio by a factor of 2.4. In addition, subtraction of photoacoustic signals that arise from light absorption within the skull significantly improved the contrast of the target. Our results indicate that PAT can potentially be applied to in vivo human brain imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.