ArticleMolecular and cellular endocrinology2013
Estrogen-related receptor α in normal adrenal cortex and adrenocortical tumors: involvement in development and oncogenesis.
Article in Molecular and cellular endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Sexual dimorphism in benign adrenocortical tumours.European journal of endocrinology · 2025Review
- Modulation of Autophagy in Adrenal Tumors.Frontiers in endocrinology · 2022Review
- Sex Differences on Mitotane Concentration and Treatment Outcome in Patients with Adrenocortical Carcinoma.Life (Basel, Switzerland) · 2021Article
- Cholesterol as an Endogenous ERRα Agonist: A New Perspective to Cancer Treatment.Frontiers in endocrinology · 2018Review
- Prognostic Factors for Adrenocortical Carcinoma Outcomes.Frontiers in endocrinology · 2016Article
- Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC).Oncotarget · 2015Article
- 3β-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma.Molecular and cellular endocrinology · 2015Article
- Metallothionein-3 (MT-3) in the human adrenal cortex and its disorders.Endocrine pathology · 2014Article
- PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.Journal of molecular endocrinology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
aimsThe nuclear hormone receptor estrogen-related receptor α (ERRα) regulates the activation of mitochondrial genes in various human tissues, but its role in the adrenal gland and its disorders has not been defined. Therefore, we examined ERRα expression in both normal adrenal cortex (NAC) and adrenocortical tumor (ACT) in order to study the possible correlation of ERRα with adrenal development and tumor development.
methodsHuman adrenal specimens (non-pathological fetal n=7; non-pathological post-birth n=40; aldosterone producing adenoma (APA) n=11; cortisol producing adenoma (CPA) n=11; adrenocortical carcinoma (ACC) n=8) were immunohistochemically examined in this study. NAC (n=13) and ACT (n=28) frozen tissue specimens were also available for studying ERRα mRNA levels. KEY
findingsIn fetal NAC tissues, ERRα labeling index (LI) in fetal zone (FZ) was significantly higher that that in neocortex (NC), and the differences among age groups for overall mean LI was statistically significant when analyzed according to individual cortical layers. ERRα LI was also significantly higher in ACC than in other types of ACT. ERRα mRNA was detected in NAC and all types of ACT. SIGNIFICANCE: Results of our present study suggest a possible role of ERRα in adrenal development and ACC.
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