Evidence map›Paper›PMID 23123443›Full record

ReviewLife sciences2013

Diabetic cardiomyopathy and metabolic remodeling of the heart.

Pavan K Battiprolu, Camila Lopez-Crisosto, Zhao V Wang, Andriy Nemchenko, Sergio Lavandero, Joseph A Hill

Abstract readReview
In one paragraph

Review in Life sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Insulin-Heart Axis: Bridging Physiology to Insulin Resistance.International journal of molecular sciences · 2024
    Review
  7. Cells · 2024
    Review
  8. Article
  9. The interplay of inflammation, exosomes and CaCardiovascular diabetology · 2023
    Review
  10. Contribution of specific ceramides to obesity-associated metabolic diseases.Cellular and molecular life sciences : CMLS · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pavan K BattiproluDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
Camila Lopez-Crisosto
Zhao V Wang
Andriy Nemchenko
Sergio Lavandero
Joseph A Hill

Funding

HDAC Inhibition in Cardiac Hypertrophy and FailureR01HL080144 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2007 to 2011
$2.0M
Calcineurin-Mediated Regulation of Cardiac Ca2+ ChannelR01HL075173 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2005 to 2009
$1.7M
Foxo: Negative Regulator of Cardiac HypertrophyR01HL090842 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2009 to 2012
$1.6M
STIM1: Master Regulator of Calcium Homeostasis in CardiomyocytesR01HL120732 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2013 to 2016
$1.6M
Rodent Ultrasound Imaging SystemS10RR023729 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2009 to 2009
$290k
NCRR NIH HHS S10 RR023729NHLBI NIH HHS HL-075173NHLBI NIH HHS HL-080144NHLBI NIH HHS HL-090842NHLBI NIH HHS R01 HL075173NHLBI NIH HHS R01 HL080144NHLBI NIH HHS R01 HL090842NHLBI NIH HHS R01 HL120732
6 · The paper itself

Abstract

The incidence and prevalence of diabetes mellitus are both increasing rapidly in societies around the globe. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, the diabetic milieu is itself intrinsically noxious to the heart, and cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease. This process, termed diabetic cardiomyopathy, is characterized by significant changes in the physiology, structure, and mechanical function of the heart. Presently, therapy for patients with diabetes focuses largely on glucose control, and attention to the heart commences with the onset of symptoms. When the latter develops, standard therapy for heart failure is applied. However, recent studies highlight that specific elements of the pathogenesis of diabetic heart disease are unique, raising the prospect of diabetes-specific therapeutic intervention. Here, we review recently unveiled insights into the pathogenesis of diabetic cardiomyopathy and associated metabolic remodeling with an eye toward identifying novel targets with therapeutic potential.

Indexed as

Ventricular RemodelingDiabetic CardiomyopathiesDrug Delivery SystemsHumans

Identifiers

PMID23123443
PMCPMC3593804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.