ArticleExperimental neurology2013
Fiber tract stimulation can reduce epileptiform activity in an in-vitro bilateral hippocampal slice preparation.
Article in Experimental neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Transcranial Focused Ultrasound Stimulation Targeting White Matter Inhibits Seizures in a Rat Model of Epilepsy.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Article
- Spatial and amplitude dynamics of neurostimulation: Insights from the acute intrahippocampal kainate seizure mouse model.Epilepsia open · 2024Article
- High and Low-Frequency Stimulation Effect on Epileptiform Activity in Brain Slices.Medical journal of the Islamic Republic of Iran · 2023Article
- Article
- Combination of Matching Responsive Stimulations of Hippocampus and Subiculum for Effective Seizure Suppression in Temporal Lobe Epilepsy.Frontiers in neurology · 2021Article
- Article
- Electrical stimulation of the endopiriform nucleus attenuates epilepsy in rats by network modulation.Annals of clinical and translational neurology · 2020Article
- Examinations of Bilateral Epileptiform Activities in Hippocampal Slices Obtained From Young Mice.Frontiers in cellular neuroscience · 2020Article
- White Matter Network Architecture Guides Direct Electrical Stimulation through Optimal State Transitions.Cell reports · 2019Article
- Corpus callosum low-frequency stimulation suppresses seizures in an acute rat model of focal cortical seizures.Epilepsia · 2018Article
- Low Frequency Electrical Stimulation Attenuated The Epileptiform Activity-Induced Changes in Action Potential Features in Hippocampal CA1 Pyramidal Neurons.Cell journal · 2018Article
- Computational modeling of epileptiform activities in medial temporal lobe epilepsy combined with in vitro experiments.Journal of computational neuroscience · 2016Article
- Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation.Experimental neurology · 2015Article
- Future of seizure prediction and intervention: closing the loop.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2015Review
- Mechanism of highly synchronized bilateral hippocampal activity.Experimental neurology · 2014Article
- TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo.Experimental neurology · 2013Article
- Long-lasting hyperpolarization underlies seizure reduction by low frequency deep brain electrical stimulation.The Journal of physiology · 2013Article
- Mechanisms of Neurostimulation for Epilepsy.Epilepsy currentsArticle
- Treating Seizures With Low-Frequency Electrical Stimulation.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Mesial temporal lobe epilepsy (MTLE) is a common medically refractory neurological disease that has been treated with electrical stimulation of gray matter with limited success. However, stimulation of a white matter tract connecting the hippocampi could maximize treatment efficacy and extent. We tested low-frequency stimulation (LFS) of a novel target that enables simultaneous targeting of bilateral hippocampi: the ventral hippocampal commissure (VHC) with a novel in-vitro slice preparation containing bilateral hippocampi connected by the VHC. The goal of this study is to understand the role of hippocampal interplay in seizure propagation and reduction by commissural fiber tract stimulation. LFS is applied to the VHC as extracellular and intracellular recording techniques are combined with signal processing to estimate several metrics of epilepsy including: (1) total time occupied by seizure activity (%); (2) seizure duration (s); (3) seizures per minute (#); and (4) power in the ictal (V(2)Hz(-1)); as well as (5) interictal spectra (V(2)Hz(-1)). Bilateral epileptiform activity in this preparation is highly correlated between hippocampi. Application of LFS to the VHC reduces all metrics of epilepsy during treatment in an amplitude and frequency dependent manner. This study lends several insights into the mechanisms of bilateral seizure reduction by LFS of the VHC, including that depolarization blocking, LTD/LTP and GABA(A) are not involved. Importantly, enhanced post-stimulation 1-Hz spiking correlates with long-lasting seizure reduction and both are heightened by targeting bilateral hippocampi via the VHC. Therefore, stimulating bilateral hippocampi via a single electrode in the VHC may provide an effective MTLE treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.