ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Peripheral resistance: a link between global airflow obstruction and regional ventilation distribution.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Electrical impedance tomography-based temporal signals correlate with quantitative computed tomography-based spatial variables in asthma subjects: a pilot study.Frontiers in physiology · 2025Article
- Mechanisms of airway remodeling converge at the critical point of bronchoconstriction in asthma.Annals of translational medicine · 2022Article
- Differences in Particle Deposition Between Members of Imaging-Based Asthma Clusters.Journal of aerosol medicine and pulmonary drug delivery · 2019Article
- 1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Understanding Pathophysiological Concepts Leading to Obstructive Apnea.Obesity surgery · 2018Review
- Elevation in lung volume and preventing catastrophic airway closure in asthmatics during bronchoconstriction.PloS one · 2018Article
- Contributions of Kinetic Energy and Viscous Dissipation to Airway Resistance in Pulmonary Inspiratory and Expiratory Airflows in Successive Symmetric Airway Models With Various Bifurcation Angles.Journal of biomechanical engineering · 2018Article
- Gravity outweighs the contribution of structure to passive ventilation-perfusion matching in the supine adult human lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- A four-dimensional computed tomography comparison of healthy and asthmatic human lungs.Journal of biomechanics · 2017Article
- The effect of disease and respiration on airway shape in patients with moderate persistent asthma.PloS one · 2017Article
- Validating Whole-Airway CFD Predictions of DPI Aerosol Deposition at Multiple Flow Rates.Journal of aerosol medicine and pulmonary drug delivery · 2016Article
- Quantification of heterogeneity in lung disease with image-based pulmonary function testing.Scientific reports · 2016Article
- Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung.Journal of aerosol medicine and pulmonary drug delivery · 2016Review
- What Causes Uneven Aerosol Deposition in the Bronchoconstricted Lung? A Quantitative Imaging Study.Journal of aerosol medicine and pulmonary drug delivery · 2016Article
- MATHEMATICAL MODELING OF VENTILATION DEFECTS IN ASTHMA.Drug discovery today. Disease models · 2015Article
- Airflow and particle deposition simulations in health and emphysema: from in vivo to in silico animal experiments.Annals of biomedical engineering · 2014Article
- Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Airflow obstruction and heterogeneities in airway constriction and ventilation distribution are well-described prominent features of asthma. However, the mechanistic link between these global and regional features has not been well defined. We speculate that peripheral airway resistance (R(p)) may provide such a link. Structural and functional parameters are estimated from PET and HRCT images of asthmatic (AS) and nonasthmatic (NA) subjects measured at baseline (BASE) and post-methacholine challenge (POST). Conductances of 35 anatomically defined proximal airways are estimated from airway geometry obtained from high-resolution computed tomography (HRCT) images. Compliances of sublobar regions subtended by 19 most distal airways are estimated from changes in regional gas volume between two lung volumes. Specific ventilations (sV) of these sublobar regions are evaluated from 13NN-washout PET scans. For each pathway connecting the trachea to sublobar region, values of R(p) required to explain the sV distribution and global airflow obstruction are computed. Results show that R(p) is highly heterogeneous within each subject, but has average values consistent with global values in the literature. The contribution of R(p) to total pathway resistance (R(T)) increased substantially for POST (P < 0.0001). The fraction R(p)/R(T) was higher in AS than NA at POST (P < 0.0001) but similar at BASE (range: 0.960-0.997, median: 0.990). For POST, R(p)/R(T) range was 0.979-0.999 (NA) and 0.981-0.995 (AS). This approach allows for estimations of peripheral airway resistance within anatomically defined sublobar regions in vivo human lungs and may be used to evaluate peripheral effects of therapy in a subject specific manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.