Evidence map›Paper›PMID 23123228›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2013

Predictors of progression to severe Alzheimer's disease in an incidence sample.

Peter V Rabins, Sarah Schwartz, Betty S Black, Christopher Corcoran, Elizabeth Fauth, Michele Mielke, Jessica Christensen, Constantine Lyketsos, Joann Tschanz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Observational
  8. Identifying and Diagnosing TDP-43 Neurodegenerative Diseases in Psychiatry.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Review
  9. Article
  10. Article
  11. Article
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  13. Observational
  14. Article
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  16. Caregiver-Care Recipient Relationship Closeness is Associated With Neuropsychiatric Symptoms in Dementia.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter V RabinsDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA. pvrabins@jhmi.edu
Sarah Schwartz
Betty S Black
Christopher Corcoran
Elizabeth Fauth
Michele Mielke
Jessica Christensen
Constantine Lyketsos
Joann Tschanz

Funding

EPIDEMIOLOGY OF DEMENTIA IN CACHE COUNTY, UTAHR01AG011380 · NIA · JOHNS HOPKINS UNIVERSITY · PI WELSH-BOHMER, KATHLEEN ANNE · 1994 to 2009
$12.2M
Progression of Dementia: A Population StudyR01AG021136 · NIA · UTAH STATE UNIVERSITY · PI LYKETSOS, CONSTANTINE G, TSCHANZ, JOANN T · 2002 to 2010
$6.0M
THE CACHE COUNTY FAMILY BASED COHORT STUDY ON AGINGR01AG018712 · NIA · UTAH STATE UNIVERSITY · PI MUNGER, RONALD G · 2000 to 2002
$2.0M
NIA NIH HHS R01 AG011380NIA NIH HHS R01 AG018712NIA NIH HHS R01 AG021136NIA NIH HHS R01AG11380NIA NIH HHS R01AG18712NIA NIH HHS R01AG21136
6 · The paper itself

Abstract

backgroundLittle is known about factors influencing time to severe Alzheimer's disease (AD).

methodsIncident cases of AD in the cache county memory study were identified. Severe AD was defined as mini-mental state examination score of ≤10 or Clinical Dementia Rating Scale score of 3; cases with either mini-mental state examination score of ≥16 or clinical dementia rating <2 were not categorized as severe AD. Kaplan-Meier, log-rank tests, and Cox analyses were used to identify demographic, clinical, and genetic correlates of time to progression to severe AD.

resultsSixty-eight of 335 cases of incident AD developed severe dementia. In bivariate analyses, female gender, less than high school education, at least one clinically significant Neuropsychiatric Inventory domain at baseline, and the youngest and oldest ages exhibited shorter time to severe AD. In competing risk analysis, subjects with mild or at least one clinically significant neuropsychiatric inventory domain score, and subjects with worse health were more likely to progress to severe dementia or death.

conclusionsDemographic and clinical variables predict progression to severe AD. Further study should examine whether these relationships are causal or correlational.

Indexed as

Disease ProgressionAgedAged, 80 and overAlzheimer DiseaseFemaleHumansMaleNeuropsychological TestsRisk Factors

Identifiers

PMID23123228
PMCPMC3791880

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.