ArticlePhytomedicine : international journal of phytotherapy and phytopharmacology2012
The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice.
Article in Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- Trial
- Efficacy and safety ofBMJ open · 2025Article
- Characterization of Starches FromInternational journal of food science · 2025Article
- Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases.Molecular neurobiology · 2024Review
- Puerarin alleviates apoptosis and inflammation in kidney stone cells via the PI3K/AKT pathway: Network pharmacology and experimental verification.Journal of cellular and molecular medicine · 2024Article
- Free and bound phenolic profiles ofFood chemistry: X · 2024Article
- Transcriptome profiling reveals the genes involved in tuberous root expansion in Pueraria (Pueraria montana var. thomsonii).BMC plant biology · 2023Article
- Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats.Molecules (Basel, Switzerland) · 2022Article
- Gut Microbiome: The Interplay of an "Invisible Organ" with Herbal Medicine and Its Derived Compounds in Chronic Metabolic Disorders.International journal of environmental research and public health · 2022Review
- RNA-Seq Analysis Reveals the Potential Molecular Mechanisms of Puerarin on Intramuscular Fat Deposition in Heat-Stressed Beef Cattle.Frontiers in nutrition · 2022Article
- Effects of puerarin on chronic inflammation: Focus on the heart, brain, and arteries.Aging medicine (Milton (N.S.W)) · 2021Review
- Metabolomic profiling to reveal the therapeutic potency ofRSC advances · 2021Article
- Traditionally Used Plants in the Treatment of Diabetes Mellitus: Screening for Uptake Inhibition of Glucose and Fructose in the Caco2-Cell Model.Frontiers in pharmacology · 2021Article
- Puerarin protects vascular smooth muscle cells from oxidized low-density lipoprotein-induced reductions in viability via inhibition of the p38 MAPK and JNK signaling pathways.Experimental and therapeutic medicine · 2020Article
- Lactate-FortifiedNutrients · 2020Article
- Effects of puerarin on the AKT signaling pathway in bovine preadipocyte differentiation.Asian-Australasian journal of animal sciences · 2020Article
- Comparison among Activities and Isoflavonoids fromMolecules (Basel, Switzerland) · 2019Article
- Fushiming Capsule Attenuates Diabetic Rat Retina Damage via Antioxidation and Anti-Inflammation.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect.Acta pharmaceutica Sinica. B · 2019Article
- Puerarin prevents high-fat diet-induced obesity by enriching Akkermansia muciniphila in the gut microbiota of mice.PloS one · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The incidence of type 2 diabetes and metabolic disease is rapidly increasing, but effective therapies for their prevention and treatment have been poorly tolerated or minimally effective. In this study, chronic administration of kudzu root extract (8 months, 0.2%, w/w, in diet) decreased baseline fasting plasma glucose (183±14 vs. 148±11 mg/dl) and improved glucose and insulin tolerance in C57BL/6J ob/ob mice (1.67±0.17 ng/ml [kudzu treated] vs. 2.35±0.63 ng/ml [control]), but such treatment did not alter these parameters in lean control mice. Among the mice on the kudzu supplementation, plasma levels of isoflavone metabolites were significantly higher in ob/ob versus lean control mice, and unmetabolized puerarin (11.50±5.63 ng/g) was found in adipose tissue only in the treated mice. Together, these data demonstrate that a puerarin containing kudzu diet improves glucose and insulin responsiveness in ob/ob mice, suggesting that puerarin may be a beneficial adjuvant for treating metabolic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.