ArticleStructure (London, England : 1993)2012
Promiscuous interactions of gp78 E3 ligase CUE domain with polyubiquitin chains.
Article in Structure (London, England : 1993), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Exploring Sulfur Sites in Proteins via Triple-ResonanceJournal of the American Chemical Society · 2023Article
- A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation.PLoS biology · 2021Article
- Ubiquitination in the ERAD Process.International journal of molecular sciences · 2020Review
- NMR Characterization of Conformational Interconversions of Lys48-Linked Ubiquitin Chains.International journal of molecular sciences · 2020Article
- A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi.Nature communications · 2020Article
- An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure.Structure (London, England : 1993) · 2020Article
- Optimization of sortase A ligation for flexible engineering of complex protein systems.The Journal of biological chemistry · 2020Article
- Enhancing NMR derived ensembles with kinetics on multiple timescales.Journal of biomolecular NMR · 2020Article
- A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.Structure (London, England : 1993) · 2019Article
- Disruption of gene SPL35, encoding a novel CUE domain-containing protein, leads to cell death and enhanced disease response in rice.Plant biotechnology journal · 2019Article
- Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13.Cell discovery · 2019Article
- Ubc7/Ube2g2 ortholog in Entamoeba histolytica: connection with the plasma membrane and phagocytosis.Parasitology research · 2018Article
- A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.Nature · 2017Article
- A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains.EMBO reports · 2017Article
- Comparison of native and non-native ubiquitin oligomers reveals analogous structures and reactivities.Protein science : a publication of the Protein Society · 2016Article
- Efficient and generalized processing of multidimensional NUS NMR data: the NESTA algorithm and comparison of regularization terms.Journal of biomolecular NMR · 2015Article
- Structural characterization of the late competence protein ComFB from Bacillus subtilis.Bioscience reports · 2015Article
- gp78 elongates of polyubiquitin chains from the distal end through the cooperation of its G2BR and CUE domains.Scientific reports · 2014Article
- The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation.The Journal of biological chemistry · 2014Article
- Cleaning up in the endoplasmic reticulum: ubiquitin in charge.Nature structural & molecular biology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Recognition of ubiquitin and polyubiquitin chains by ubiquitin-binding domains (UBDs) is vital for ubiquitin-mediated signaling pathways. The endoplasmic reticulum resident RING finger ubiquitin ligase (E3) gp78 regulates critical proteins via the ubiquitin-proteasome system to maintain cellular homeostasis and includes a UBD known as the CUE domain, which is essential for function. A probable role of this domain is to recognize ubiquitin-modified substrates, enabling gp78 to assemble polyubiquitin chains on these substrates and mark them for degradation. Here, we report the molecular details of the interaction of gp78CUE domain with ubiquitin and diubiquitin. The gp78CUE domain exhibits a well-defined set of interactions with ubiquitin and a dynamic, promiscuous interaction with diubiquitin chains. This leads to a model in which the CUE domain functions to both facilitate substrate binding and enable switching between adjacent ubiquitin molecules of a growing chain to enable processivity in ubiquitination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.