ArticleDevelopmental cell2012
Silencing of germline-expressed genes by DNA elimination in somatic cells.
Article in Developmental cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 114 citations in OpenAlex.
- Comparison of real-time PCR and the Kato-Katz method for the diagnosis of soil-transmitted helminthiasis and assessment of cure in a randomized controlled trial.BMC microbiology · 2020Trial
- The mechanistic and evolutionary diversity of programmed DNA elimination.Nature reviews. Genetics · 2026Review
- Programmed DNA elimination was present in the last common ancestor ofbioRxiv : the preprint server for biology · 2026Article
- Widespread gene fusion artifacts in helminth genome annotations.BMC genomics · 2026Article
- Argonautes and small RNAs associated with nematode programmed DNA elimination.bioRxiv : the preprint server for biology · 2025Article
- The biological and evolutionary consequences of competition between DNA sequences that benefit the cell and DNA sequences that benefit themselves.Nucleic acids research · 2025Review
- Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment.Nature communications · 2025Article
- Functions and mechanisms of eukaryotic RNA-guided programmed DNA elimination.Biochemical Society transactions · 2025Review
- Article
- End resection and telomere healing of DNA double-strand breaks during nematode programmed DNA elimination.Nucleic acids research · 2024Article
- Chromosome fusion and programmed DNA elimination shape karyotypes of nematodes.Current biology : CB · 2024Article
- End resection and telomere healing of DNA double-strand breaks during nematode programmed DNA elimination.bioRxiv : the preprint server for biology · 2024Article
- Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids.Advances in parasitology · 2024Article
- Chromosome fusion and programmed DNA elimination shape karyotypes of parasitic nematodes.bioRxiv : the preprint server for biology · 2023Article
- Programmed DNA elimination in the parasitic nematode Ascaris.PLoS pathogens · 2023Review
- Article
- Novel selectively amplified DNA sequences in the germline genome of the Japanese hagfish, Eptatretus burgeri.Scientific reports · 2022Article
- The nematode Oscheius tipulae as a genetic model for programmed DNA elimination.Current biology : CB · 2022Article
- Nematode chromosomes.Genetics · 2022Review
- Absence of Polymorphisms in Codons 167, 198 and 200 of All Seven β-Tubulin Isotypes of Benzimidazole Susceptible and ResistantPathogens (Basel, Switzerland) · 2022Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Chromatin diminution is the programmed elimination of specific DNA sequences during development. It occurs in diverse species, but the function(s) of diminution and the specificity of sequence loss remain largely unknown. Diminution in the nematode Ascaris suum occurs during early embryonic cleavages and leads to the loss of germline genome sequences and the formation of a distinct genome in somatic cells. We found that ∼43 Mb (∼13%) of genome sequence is eliminated in A. suum somatic cells, including ∼12.7 Mb of unique sequence. The eliminated sequences and location of the DNA breaks are the same in all somatic lineages from a single individual and between different individuals. At least 685 genes are eliminated. These genes are preferentially expressed in the germline and during early embryogenesis. We propose that diminution is a mechanism of germline gene regulation that specifically removes a large number of genes involved in gametogenesis and early embryogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.