ArticleVirology2013
Antigenic characterization of recent H5N1 highly pathogenic avian influenza viruses circulating in Egyptian poultry.
Article in Virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Mapping hemagglutinin residues driving antigenic diversity in H5Nx avian influenza viruses.Journal of virology · 2026Article
- Multiple transatlantic incursions of highly pathogenic avian influenza clade 2.3.4.4b A(H5N5) virus into North America and spillover to mammals.Cell reports · 2024Article
- Reassortments among Avian Influenza A(H5N1) Viruses Circulating in Indonesia, 2015-2016.Emerging infectious diseases · 2019Article
- Broadening the H5N3 Vaccine Immunogenicity against H5N1 Virus by Modification of Neutralizing Epitopes.Viruses · 2017Article
- Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses.Journal of virology · 2017Article
- Visualization of Alternative Functional Configurations of Influenza Virus Hemagglutinin Facilitates Rapid Selection of Complementing Vaccines in Emergency Situations.International journal of molecular sciences · 2017Article
- Phylodynamics of avian influenza clade 2.2.1 H5N1 viruses in Egypt.Virology journal · 2016Article
- Article
- Variation in protection of four divergent avian influenza virus vaccine seed strains against eight clade 2.2.1 and 2.2.1.1. Egyptian H5N1 high pathogenicity variants in poultry.Influenza and other respiratory viruses · 2014Article
- Antigenic and genetic evolution of low-pathogenicity avian influenza viruses of subtype H7N3 following heterologous vaccination.Clinical and vaccine immunology : CVI · 2014Article
- Antigenic characterization of H3N2 influenza A viruses from Ohio agricultural fairs.Journal of virology · 2013Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
The extensive circulation of Highly Pathogenic (HP) H5N1 Avian Influenza in Egypt in poultry since 2006 resulted in the emergence of distinct clades with the recent identification of a further clade: 2.2.1.1. The aim of this study was to characterize for the first time the antigenic profile of an extensive collection of genetically diverse Egyptian H5N1 HP viruses isolated between 2007 and 2010 applying antigenic cartography and principal component analysis to serological data. We identified that Egyptian H5N1 viruses have undergone significant antigenic diversification between 2007 and 2010 and two distinct antigenic clusters co-circulated in 2010. Such clusters correlated with 2.2.1 and 2.2.1.1 clades, showing for the first time that the new emerging clade 2.2.1.1 is antigenically distinct. This study highlights that the antigenic diversity of H5N1 HP Egyptian viruses may represent a potential challenge for the development of an effective vaccination programme for animal and human health in Egypt.
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