Evidence map›Paper›PMID 23122590›Full record

ArticleAmerican journal of human genetics2012

Linkage-disequilibrium-based binning misleads the interpretation of genome-wide association studies.

Xiaofeng Zhu, Tao Feng, Robert C Elston

Abstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Xiaofeng Zhu
Tao Feng
Robert C Elston

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Geisinger eGenonic Medicine (GeM) ProgramU01HG006382 · NHGRI · GEISINGER CLINIC · PI CAREY, DAVID J., WILLIAMS, MARC S. · 2011 to 2014
$4.3M
Statistical methods for analyzing high-throughput genotype dataR01HG003054 · NHGRI · LOYOLA UNIVERSITY CHICAGO · PI ZHU, XIAOFENG · 2005 to 2017
$3.6M
Fine Mapping of Hypertension Genes Detected by Admixture Mapping in the FBPPR01HL086718 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ZHU, XIAOFENG · 2007 to 2011
$3.3M
Statistical Methods for Gene Mapping Studies in Admixed PopulationsR01HG005854 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI LI, MINGYAO · 2010 to 2012
$978k
Role of Mitochondrial CYP2E1 in Chemical Exposure-Driven NeurodegenerationF32ES027306 · NIEHS · DUKE UNIVERSITY · PI HARTMAN, JESSICA HELENE · 2016 to 2018
$171k
NHGRI NIH HHS HG003054NHGRI NIH HHS HG005854NHGRI NIH HHS R01 HG003054NHGRI NIH HHS R01 HG005854NHGRI NIH HHS U01 HG006382NHGRI NIH HHS U01HG006382NHLBI NIH HHS HL086718NHLBI NIH HHS R01 HL086718NIEHS NIH HHS 27306C0004
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genome-Wide Association StudyHumansLinkage Disequilibrium

Identifiers

PMID23122590
PMCPMC3487138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.