ArticleCellular immunology
In vivo imaging implicates CCR2(+) monocytes as regulators of neutrophil recruitment during arthritis.
Article in Cellular immunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Acute kidney injury triggers hypoxemia by lung intravascular neutrophil retention that reduces capillary blood flow.The Journal of clinical investigation · 2025Article
- Chemokines and chemokine receptors as promising targets in rheumatoid arthritis.Frontiers in immunology · 2023Review
- Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain.Brain, behavior, and immunity · 2022Article
- Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment.JCI insight · 2021Article
- A basophil-neuronal axis promotes itch.Cell · 2021Article
- Complement activation on neutrophils initiates endothelial adhesion and extravasation.Molecular immunology · 2019Article
- Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases.The Journal of clinical investigation · 2017Article
- Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis.Arthritis research & therapy · 2017Article
- Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state.Mucosal immunology · 2017Article
- Noninvasive Imaging of CCR2American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016Article
- Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review.Clinical reviews in allergy & immunology · 2016Review
- A Critical Role for Monocytes/Macrophages During Intestinal Inflammation-associated Lymphangiogenesis.Inflammatory bowel diseases · 2016Article
- Critical role of the C5a-activated neutrophils in high-fat diet-induced vascular inflammation.Scientific reports · 2016Article
- Cellular imaging in rheumatic diseases.Nature reviews. Rheumatology · 2015Review
- Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria.PloS one · 2015Article
- CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis.Journal of virology · 2014Article
- In vivo imaging reveals a pioneer wave of monocyte recruitment into mouse skin wounds.PloS one · 2014Article
- Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs.PloS one · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The infiltration of neutrophils and monocytes is a prominent feature of inflammatory diseases including human rheumatoid arthritis. Understanding how neutrophil recruitment is regulated during pathogenesis is crucial for developing anti-inflammatory therapies. We optimized the K/B×N serum-induced mouse arthritis model to study neutrophil trafficking dynamics in vivo using two-photon microscopy. Arthritogenic serum was injected subcutaneously into one hind footpad to induce a local arthritis with robust neutrophil recruitment. Using this approach, we showed that the depletion of monocytes with clodronate liposomes impaired neutrophil recruitment specifically at the transendothelial migration step. The depletion of CCR2(+) monocytes with the monoclonal antibody MC-21 reproduced these effects, implicating CCR2(+) monocytes as key regulators of neutrophil extravasation during arthritis initiation. However, monocyte depletion did not prevent neutrophil extravasation in response to bacterial challenge. These findings suggest that anti-inflammatory therapies targeting monocytes may act in part through antagonizing neutrophil extravasation at sites of aseptic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.