ArticleMolecular microbiology2012
A translocator-specific export signal establishes the translocator-effector secretion hierarchy that is important for type III secretion system function.
Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- On the role of the sorting platform in hierarchical type III secretion regulation in enteropathogenicJournal of bacteriology · 2025Article
- Virulence and Metabolism Crosstalk: Impaired Activity of the Type Three Secretion System (T3SS) in aInternational journal of molecular sciences · 2023Article
- Virulence-associated type III secretion systems in Gram-negative bacteria.Microbiology (Reading, England) · 2023Review
- Article
- A Transfer-Learning-Based Deep Convolutional Neural Network for Predicting Leukemia-Related Phosphorylation Sites from Protein Primary Sequences.International journal of molecular sciences · 2022Article
- Transmembrane domains of type III-secreted proteins affect bacterial-host interactions in enteropathogenicVirulence · 2021Article
- Cell-type-specific hypertranslocation of effectors by the Pseudomonas aeruginosa type III secretion system.Molecular microbiology · 2021Article
- A Structure-Function-Inhibition Analysis of theJournal of bacteriology · 2020Article
- TheThe Journal of biological chemistry · 2018Article
- Assembly, structure, function and regulation of type III secretion systems.Nature reviews. Microbiology · 2017Review
- Type III-Dependent Translocation of HrpB2 by a Nonpathogenic hpaABC Mutant of the Plant-Pathogenic Bacterium Xanthomonas campestris pv. vesicatoria.Applied and environmental microbiology · 2016Article
- The Type III Secretion Translocation Pore Senses Host Cell Contact.PLoS pathogens · 2016Article
- YopN and TyeA Hydrophobic Contacts Required for Regulating Ysc-Yop Type III Secretion Activity by Yersinia pseudotuberculosis.Frontiers in cellular and infection microbiology · 2016Article
- Type III secretion systems: the bacterial flagellum and the injectisome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- SepD/SepL-dependent secretion signals of the type III secretion system translocator proteins in enteropathogenic Escherichia coli.Journal of bacteriology · 2015Article
- Transcriptional profiling of Vibrio parahaemolyticus exsA reveals a complex activation network for type III secretion.Frontiers in microbiology · 2015Article
- A gatekeeper chaperone complex directs translocator secretion during type three secretion.PLoS pathogens · 2014Article
- Control of type III secretion activity and substrate specificity by the cytoplasmic regulator PcrG.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A shotgun antisense approach to the identification of novel essential genes in Pseudomonas aeruginosa.BMC microbiology · 2014Article
- Dimerization of the Pseudomonas aeruginosa translocator chaperone PcrH is required for stability, not function.Journal of bacteriology · 2013Article
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4 authors.
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Abstract
Type III secretion systems are used by many Gram-negative pathogens to directly deliver effector proteins into the cytoplasm of host cells. To accomplish this, bacteria secrete translocator proteins that form a pore in the host-cell membrane through which the effector proteins are then introduced into the host cell. Evidence from multiple systems indicates that the pore-forming translocator proteins are exported before effectors, but how this secretion hierarchy is established is unclear. Here we used the Pseudomonas aeruginosa translocator protein PopD as a model to identify its export signals. The N-terminal secretion signal and chaperone, PcrH, are required for export under all conditions. Two novel signals in PopD, one proximal to the chaperone binding site and one at the very C-terminus of the protein, are required for export of PopD before effector proteins. These novel export signals establish the translocator-effector secretion hierarchy, which in turn, is critical for the delivery of effectors into host cells.
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