ArticleJournal of oral microbiology2012
The oral microflora in obesity and type-2 diabetes.
Article in Journal of oral microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Advances in the study of oral microbiota in association with T2DM: a systematic review.Frontiers in cellular and infection microbiology · 2025Pooled it
- The salivary microbiome is altered in the presence of a high salivary glucose concentration.PloS one · 2017Trial
- Characterizing the tuberculosis and type 2 diabetes mellitus comorbidity in a South African cohort using untargeted GCxGC-TOFMS metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Biofilms and oral health: nanotechnology for biofilm control.Discover nano · 2025Review
- Potential Shifts in the Oral Microbiome Induced by Bariatric Surgery-A Scoping Review.Antibiotics (Basel, Switzerland) · 2025Review
- Diet type and the oral microbiome.Frontiers in nutrition · 2025Review
- Multi-omics approaches for biomarker discovery and precision diagnosis of prediabetes.Frontiers in endocrinology · 2025Review
- Exploring essential oil-based bio-composites: molecular docking andFrontiers in chemistry · 2024Article
- Influence of Bariatric Surgery on Oral Microbiota: A Systematic Review.European journal of dentistry · 2023Article
- The role of the oral microbiome in obesity and metabolic disease: potential systemic implications and effects on taste perception.Nutrition journal · 2023Review
- A Positive or Negative Connection of Diabetes Mellitus to the Oral Microbiota.The Eurasian journal of medicine · 2023Article
- Studying ancient human oral microbiomes could yield insights into the evolutionary history of noncommunicable diseases.F1000Research · 2023Review
- Dental Composites with Magnesium Doped Zinc Oxide Nanoparticles Prevent Secondary Caries in the Alloxan-Induced Diabetic Model.International journal of molecular sciences · 2022Article
- Prevalence of Microorganisms in Atherosclerotic Plaques of Coronary Arteries: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Oral Bacterial Microbiomes in Association with Potential Prediabetes Using Different Criteria of Diagnosis.International journal of environmental research and public health · 2021Article
- Salivary microbiome composition changes after bariatric surgery.Scientific reports · 2020Article
- Salivary Microbiological and Gingival Health Status Evaluation of Adolescents With Overweight and Obesity: A Cluster Analysis.Frontiers in pediatrics · 2020Article
- Association of the oral microbiome with the progression of impaired fasting glucose in a Chinese elderly population.Journal of oral microbiology · 2019Article
- Obesity, salivary glands and oral pathology.Colombia medica (Cali, Colombia) · 2018Review
- Citizen science charts two major "stomatotypes" in the oral microbiome of adolescents and reveals links with habits and drinking water composition.Microbiome · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundType 2 diabetes mellitus (T2DM) is prevalent in people with obesity. It has been proposed that these conditions are related to specific features of the microflora of the mouth and lower gastrointestinal (GI) tract. Hyperglycemia often resolves quickly after Roux-en-Y gastric bypass (RYGB) but the role of the GI microflora cannot be examined easily because of reduced intestinal mobility. We propose that the study of microorganisms present in the mouth of patients undergoing RYGB will contribute to our understanding of the role of bacteria in the pathogenesis of T2DM.
objectiveTo conduct a feasibility study to examine differences in oral microbes in obese patients with and without T2DM and to determine whether it is feasible to measure changes after gastric bypass surgery.
methodsIndividuals with morbid obesity (n=29), of whom 13 had T2DM, were studied. Oral rinses, stool samples, and blood samples were obtained before RYGB, and oral rinses and blood samples were obtained at 2 and 12 weeks postsurgery.
resultsPrior to surgery, participants with T2DM had slightly higher total levels of oral bacteria than those without diabetes. Those with HbA1c > 6.5% had rather lower levels of Bifidobacteria in the mouth and stool. At 2 weeks post-RYGB, patients with T2DM were able to reduce or discontinue their hypoglycemic medications. Stool samples could not be obtained but oral rinses were readily available. The levels of oral Bifidobacteria had increased tenfold and levels of circulating endotoxin and tumor necrosis factor-alpha had decreased.
conclusionsThe study of oral bacteria before and after RYGB is feasible and should be tested in larger patient populations to increase our understanding of the role of microorganisms in the pathogenesis of obesity and T2DM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.