Trial reportPloS one2012
An fMRI study exploring the overlap and differences between neural representations of physical and recalled pain.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Social pain: A systematic review on interventions.F1000Research · 2025Pooled it
- Brain activations associated with fearful experience show common and distinct patterns between younger and older adults in the hippocampus and the amygdala.Scientific reports · 2018Trial
- Dyspnea-related cues engage the prefrontal cortex: evidence from functional brain imaging in COPD.Chest · 2015Trial
- Article
- Article
- Neuroscientific results of experimental studies on the control of acute pain with hypnosis and suggested analgesia.Frontiers in psychology · 2024Review
- Article
- Fading boundaries between the physical and the social world: Insights and novel techniques from the intersection of these two fields.Frontiers in psychology · 2022Review
- EEG and fMRI evidence for autobiographical memory reactivation in empathy.Human brain mapping · 2021Article
- Reactivation of Single-Episode Pain Patterns in the Hippocampus and Decision Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Hippocampus shape deformation: a potential diagnostic biomarker for chronic back pain in women.Pain · 2021Article
- Eye Movements in Response to Pain-Related Feelings in the Presence of Low and High Cognitive Loads.Behavioral sciences (Basel, Switzerland) · 2020Article
- Amygdala functional connectivity in the acute aftermath of trauma prospectively predicts severity of posttraumatic stress symptoms.Neurobiology of stress · 2020Article
- Article
- Aversive Imagery Causes De Novo Fear Conditioning.Psychological science · 2019Article
- Assessment of brain mechanisms involved in the processes of thermal sensation, pleasantness/unpleasantness, and evaluation.IBRO reports · 2019Article
- Review
- Primary Interoceptive Cortex Activity during Simulated Experiences of the Body.Journal of cognitive neuroscience · 2019Article
- Cash, Card or Smartphone: The Neural Correlates of Payment Methods.Frontiers in neuroscience · 2019Article
- Changes in spontaneous overt motor execution immediately after observing others' painful action: two pilot studies.Experimental brain research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Implementing a recall paradigm without hypnosis, we use functional MRI (fMRI) to explore and compare nociceptive and centrally-driven pain experiences. We posit that a trace of a recent nociceptive event can be used to create sensory-re-experiencing of pain that can be qualified in terms of intensity and vividness. Fifteen healthy volunteers received three levels of thermal stimuli (warm, low pain and high pain) and subsequently were asked to recall and then rate this experience. Neuroimaging results reveal that recalling a previous sensory experience activates an extensive network of classical pain processing structures except the contralateral posterior insular cortex. Nociceptive-specific activation of this structure and the rated intensity difference between physical and recalled pain events allow us to investigate the link between the quality of the original nociceptive stimulus and the mental trace, as well as the differences between the accompanying neural responses. Additionally, by incorporating the behavioural ratings, we explored which brain regions were separately responsible for generating either an accurate or vivid recall of the physical experience. Together, these observations further our understanding of centrally-mediated pain experiences and pain memory as well as the potential relevance of these factors in the maintenance of chronic pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.