ArticlePloS one2012
CD69 does not affect the extent of T cell priming.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Dendritic cell-specific hypoxia-inducible factor-1α deficiency protects mice from recurrent retroviral infection.Experimental physiology · 2026Article
- Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma.Cancer research communications · 2023Article
- Peripheral blood eosinophils priming andPostepy dermatologii i alergologii · 2021Article
- Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction.Marine drugs · 2021Article
- CD69 Targeting Enhances Anti-vaccinia Virus Immunity.Journal of virology · 2019Article
- The Functional Requirement for CD69 in Establishment of Resident Memory CD8Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Inhibiting Notch1 enhances immunotherapy efficacy in melanoma by preventing Notch1 dependent immune suppressive properties.Cancer letters · 2018Article
- [Expression and significance of endothelial microparticles in children with Henoch-Schönlein purpura].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018Article
- CD69: from activation marker to metabolic gatekeeper.European journal of immunology · 2017Review
- DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.The Journal of experimental medicine · 2017Article
- Anti-CD69 monoclonal antibody treatment inhibits airway inflammation in a mouse model of asthma.Journal of Zhejiang University. Science. B · 2015Article
- In vitro Production of IL-6 and IFN-γ is Influenced by Dietary Variables and Predicts Upper Respiratory Tract Infection Incidence and Severity Respectively in Young Adults.Frontiers in immunology · 2015Article
- CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment?Journal of immunology research · 2015Review
- The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector.BioMed research international · 2014Article
- Is CD69 an effective brake to control inflammatory diseases?Trends in molecular medicine · 2013Review
- B Lymphocytes Are the Target of Mesenchymal Stem Cells Immunoregulatory Effect in a Murine Graft-versus-Host Disease Model.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD69 is rapidly upregulated on T cells upon activation. In this work we show that this is also the case for CD69 expression on dendritic cells (DC). Thus, the expression kinetics of CD69 on both cell types is reminiscent of the one of costimulatory molecules. Using mouse models of transgenic T cells, we aimed at evaluating the effect of monoclonal antibody (MAb)-based targeting and gene deficiency of CD69 expressed by either DC or T cells on the extent of antigen (Ag)-specific T cell priming, which could be the result of a putative role in costimulation as well as on DC maturation and Ag-processing and presentation. CD69 targeting or deficiency of DC did not affect their expression of costimulatory molecules nor their capacity to induce Ag-specific T cell proliferation in in vitro assays. Also, CD69 targeting or deficiency of transgenic T cells did not affect the minimal proliferative dose for different peptide agonists in vitro. In in vivo models of transgenic T cell transfer and local Ag injection, CD69 deficiency of transferred T cells did not affect the extent of the proliferative response in Ag-draining lymph nodes (LN). In agreement with these results, CD69 MAb targeting or gene deficiency of Vaccinia-virus (VACV) infected mice did not affect the endogenous formation of virus-specific CD8(+) T cell populations at the peak of the primary immune response. Altogether our results argue against a possible role in costimulation or an effect on Ag processing and presentation for CD69.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.