ArticlePloS one2012
Short and long term measures of anxiety exhibit opposite results.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
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- Cancer and cancer survival modulates brain and behavior in a time-of-day-dependent manner in mice.Scientific reports · 2019Article
- Vertical exploration and dimensional modularity in mice.Royal Society open science · 2018Article
- Exhaustive Multi-Parametric Assessment of the Behavioral Array of Daily Activities of Mice Using Cluster and Factor Analysis.Frontiers in behavioral neuroscience · 2018Article
- Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects.Behavioural neurology · 2018Article
- Supervised and Unsupervised Learning Technology in the Study of Rodent Behavior.Frontiers in behavioral neuroscience · 2017Review
- Ethological Evaluation of the Effects of Social Defeat Stress in Mice: Beyond the Social Interaction Ratio.Frontiers in behavioral neuroscience · 2015Article
- Display of individuality in avoidance behavior and risk assessment of inbred mice.Frontiers in behavioral neuroscience · 2014Article
- Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring.PloS one · 2014Article
- Measuring behavior of animal models: faults and remedies.Nature methods · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal models of human diseases of the central nervous system, generalized anxiety disorder included, are essential for the study of the brain-behavior interface and obligatory for drug development; yet, these models fail to yield new insights and efficacious drugs. By increasing testing duration hundredfold and arena size tenfold, and comparing the behavior of the common animal model to that of wild mice, we raise concerns that chronic anxiety might have been measured at the wrong time, for the wrong duration, and in the wrong animal. Furthermore, the mice start the experimental session with a short period of transient adaptation to the novel environment (habituation period) and a long period reflecting the respective trait of the mice. Using common measures of anxiety reveals that mice exhibit opposite results during these periods suggesting that chronic anxiety should be measured during the post-habituation period. We recommend tools for measuring the transient period, and provide suggestions for characterizing the post habituation period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.