SynthesisPloS one2012
Upper and lower urinary tract outcomes in adult myelomeningocele patients: a systematic review.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Botulinum Toxin Injection for Medically Refractory Neurogenic Bladder in Children: A Systematic Review.Toxins · 2021Pooled it
- Bladder Function After Fetal Surgery for Myelomeningocele.Pediatrics · 2015Trial
- Sexual Dysfunction and Lower Urinary Tract Dysfunction in Adults With Spina Bifida.International journal of urology : official journal of the Japanese Urological Association · 2026Observational
- EAU-ESPU-ERN eUROGEN-ERN ITHACA-ERN ERKNet-IFSBH Guidelines on Spinal Dysraphism in Children and Adolescents: Summary of the Guideline.European urology open science · 2026Article
- Dynamic ultrasound evaluation of morphological and functional urinary tract characteristics in newborns and young infants with myelomeningocele.Pediatric radiology · 2026Article
- Machine Learning Analysis of Videourodynamics to Predict Incident Hydronephrosis in Patients With Spina Bifida.The Journal of urology · 2025Article
- Article
- Diagnostic Test Characteristics of Ultrasound-Based Hydronephrosis for Chronic Kidney Disease in Children and Adolescents With Myelomeningocele: Results From the UMPIRE and National Spina Bifida Patient Registry Cohort Studies.The Journal of urology · 2025Article
- Article
- Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study.Pediatric nephrology (Berlin, Germany) · 2024Article
- Myelomeningocele: the evolution of care over the last 50 years.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Risk factors for upper urinary tract deterioration in adult patients with spina bifida.World journal of urology · 2023Article
- Variation in Definitions of Kidney Abnormality in Patients with Spina Bifida: A Systematic Scoping Review.The Journal of urology · 2022Article
- Prospective Evaluation of Intradetrusor Injections of OnabotulinumtoxinA in Adults With Spinal Dysraphism.Urology · 2022Article
- Article
- Urodynamic characteristics of neurogenic bladder in newborns with myelomeningocele and refinement of the definition of bladder hostility: Findings from the UMPIRE multi-center study.Journal of pediatric urology · 2021Article
- Challenges in pediatric urologic practice: a lifelong view.World journal of urology · 2021Review
- Diagnostic Test Characteristics of Ultrasound Based Hydronephrosis in Identifying Low Kidney Function in Young Patients with Spina Bifida: A Retrospective Cohort Study.The Journal of urology · 2021Article
- Kidney Function Surveillance in the National Spina Bifida Patient Registry: A Retrospective Cohort Study.The Journal of urology · 2020Article
- A Japanese man with spina bifida who successfully fathered a child following fertility treatment.IJU case reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe introduction of sophisticated treatment of bladder dysfunction and hydrocephalus allows the majority of SB patients to survive into adulthood. However, no systematic review on urological outcome in adult SB patients is available and no follow-up schemes exist.
objectivesTo systematically summarize the evidence on outcome of urinary tract functioning in adult SB patients.
methodsA literature search in PubMed and Embase databases was done. Only papers published in the last 25 years describing patients with open SB with a mean age >18 years were included. We focused on finding differences in the treatment strategies, e.g., clean intermittent catheterization and antimuscarinic drugs versus early urinary diversion, with regard to long-term renal and bladder outcomes.
resultsA total of 13 articles and 5 meeting abstracts on urinary tract status of adult SB patients were found describing a total of 1564 patients with a mean age of 26.1 years (range 3-74 years, with a few patients <18 years). All were retrospective cohort studies with relatively small and heterogeneous samples with inconsistent reporting of outcome; this precluded the pooling of data and meta-analysis. Total continence was achieved in 449/1192 (37.7%; range 8-85%) patients. Neurological level of the lesion and hydrocephalus were associated with incontinence. Renal function was studied in 1128 adult patients. In 290/1128 (25.7%; range 3-81.8%) patients some degree of renal damage was found and end-stage renal disease was seen in 12/958 (1.3%) patients. Detrusor-sphincter dyssynergy and detrusor-overactivity acted as adverse prognostic factors for the development of renal damage.
conclusionsThese findings should outline follow-up schedules for SB patients, which do not yet exist. Since renal and bladder deterioration continues beyond adolescence, follow-up of these individuals is needed. We recommend standardization in reporting the outcome of urinary tract function in adult SB patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.