ArticlePloS one2012
Modeling and dynamical analysis of virus-triggered innate immune signaling pathways.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Article
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- A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection.bioRxiv : the preprint server for biology · 2025Article
- In Vitro and In Vivo Evaluation of Virus-Induced Innate Immunity in Mouse.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Data-driven multi-scale mathematical modeling of SARS-CoV-2 infection reveals heterogeneity among COVID-19 patients.PLoS computational biology · 2021Article
- FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2.Bioinformatics (Oxford, England) · 2020Article
- Avian Interferon-Inducible Transmembrane Protein Family Effectively Restricts Avian Tembusu Virus Infection.Frontiers in microbiology · 2017Article
- Mathematical Models for Immunology: Current State of the Art and Future Research Directions.Bulletin of mathematical biology · 2016Review
- Avian Tembusu virus infection effectively triggers host innate immune response through MDA5 and TLR3-dependent signaling pathways.Veterinary research · 2016Article
- Crosstalk between pathways enhances the controllability of signalling networks.IET systems biology · 2016Article
- Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2'-O-Methylation Mutant.PLoS pathogens · 2015Article
- Deciphering deterioration mechanisms of complex diseases based on the construction of dynamic networks and systems analysis.Scientific reports · 2015Article
- Computational Studies of the Intestinal Host-Microbiota Interactome.Computation (Basel, Switzerland) · 2015Article
- Optimal control strategy for abnormal innate immune response.Computational and mathematical methods in medicine · 2015Article
- A new asynchronous parallel algorithm for inferring large-scale gene regulatory networks.PloS one · 2015Article
- What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?Mechanisms of ageing and developmentReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The investigation of the dynamics and regulation of virus-triggered innate immune signaling pathways at a system level will enable comprehensive analysis of the complex interactions that maintain the delicate balance between resistance to infection and viral disease. In this study, we developed a delayed mathematical model to describe the virus-induced interferon (IFN) signaling process by considering several key players in the innate immune response. Using dynamic analysis and numerical simulation, we evaluated the following predictions regarding the antiviral responses: (1) When the replication ratio of virus is less than 1, the infectious virus will be eliminated by the immune system's defenses regardless of how the time delays are changed. (2) The IFN positive feedback regulation enhances the stability of the innate immune response and causes the immune system to present the bistability phenomenon. (3) The appropriate duration of viral replication and IFN feedback processes stabilizes the innate immune response. The predictions from the model were confirmed by monitoring the virus titer and IFN expression in infected cells. The results suggest that the balance between viral replication and IFN-induced feedback regulation coordinates the dynamical behavior of virus-triggered signaling and antiviral responses. This work will help clarify the mechanisms of the virus-induced innate immune response at a system level and provide instruction for further biological experiments.
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