ArticlePloS one2012
Non-specific abdominal pain and air pollution: a novel association.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 66 citations in OpenAlex.
- Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill.Particle and fibre toxicology · 2018Trial
- Association of Air Pollution and Socioeconomic Deprivation with Depression and Pain.International journal of environmental research and public health · 2026Article
- Article
- Respiratory exposure to agricultural dust extract promotes increased intestinalAmerican journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Air pollution, dysbiosis and diseases: pneumonia, asthma, COPD, lung cancer and irritable bowel syndrome.Future microbiology · 2024Review
- The Impact of Climate Change, Pollution, and Biodiversity Loss on Digestive Health and Disease.Gastro hep advances · 2024Review
- Retrospective Study on the Association Between Climate Factors and Infant Colic in Beijing (2021-2022).Journal of multidisciplinary healthcare · 2024Article
- Impacts of short-term air pollution exposure on appendicitis admissions: Evidence from one of the most polluted cities in mainland China.Frontiers in public health · 2023Article
- Deleterious Effect of Air Pollution on Human Microbial Community and Bacterial Flora: A Short Review.International journal of environmental research and public health · 2022Review
- Neuroinflammation and Neurodegeneration of the Central Nervous System from Air Pollutants: A Scoping Review.Toxics · 2022Article
- Short-term effects of ambient air pollution on daily emergency room visits for abdominal pain: a time-series study in Wuhan, China.Environmental science and pollution research international · 2022Article
- A randomization-based causal inference framework for uncovering environmental exposure effects on human gut microbiota.PLoS computational biology · 2022Article
- Association between exposure to air pollutants and the risk of inflammatory bowel diseases visits.Environmental science and pollution research international · 2022Article
- Cold Climate Impact on Air-Pollution-Related Health Outcomes: A Scoping Review.International journal of environmental research and public health · 2022Article
- Associations between air pollution and multimorbidity in the UK Biobank: A cross-sectional study.Frontiers in public health · 2022Article
- Exposure to air pollutants and the gut microbiota: a potential link between exposure, obesity, and type 2 diabetes.Gut microbes · 2020Review
- An association between air pollution and daily most frequently visits of eighteen outpatient diseases in an industrial city.Scientific reports · 2020Article
- Ambient Air Pollution and Hospital Admissions for Peptic Ulcers in Taipei: A Time-Stratified Case-Crossover Study.International journal of environmental research and public health · 2019Article
- Challenges in IBD Research: Environmental Triggers.Inflammatory bowel diseases · 2019Review
- Is Long-term Ambient Air Pollutant Exposure a Risk Factor for Irritable Bowel Syndrome in Children? A 12-year Longitudinal Cohort Study.Journal of neurogastroenterology and motility · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe studied whether short-term exposure to air pollution was associated with non-specific abdominal pain in epidemiologic and animal studies.
methodsPatients visiting the emergency department with non-specific abdominal pain were identified in Edmonton (1992 to 2002, n = 95,173) and Montreal (1997 to 2002, n = 25,852). We calculated the daily concentrations for ozone (O(3)), nitrogen dioxide (NO(2)), sulfur dioxide (SO(2)), carbon monoxide (CO), and particles <10 (PM(10)) or <2.5 (PM(2.5)) µm. A case crossover study design was used to estimate the odds ratio (OR) and 95% confidence interval (CI) associated with an increase in the interquartile range of the air pollutants. We investigated differential effects by age and sex. Mice were gavaged with urban particle extracts. In animal models, colonic motility was tested, and visceral abdominal pain was measured using a writhing test, and behavioral response to oil of mustard and neostigmine. Motility and pain was measured acutely (1.5 hours after gavage) and chronically (7-days and 21-days after gavage).
resultsEmergency department visits for non-specific abdominal pain were primarily by women between the ages of 15-24 years. Individuals aged 15 to 24 years were at increased risk of non-specific abdominal pain in Edmonton (same day CO: OR = 1.04, 95% CI = 1.02-1.06; and NO(2): OR = 1.06, 95% CI = 1.03-1.09). The risk of air pollution among 15-24 year olds in Montreal was significantly positive (same day CO: OR = 1.11, 95% CI = 1.05-1.17; NO(2): OR = 1.09, 95% CI = 1.01-1.16; SO(2): OR = 1.17, 95% CI = 1.10-1.25; PM(2.5): OR = 1.09, 95% CI = 1.04-1.15). Abdominal pain was increased by an acute gavage of pollution extract but not to chronic exposure to pollutants. Colonic transit was delayed following chronic but not acute exposure with the pollutants.
conclusionsEpidemiological and animal data suggest that short-term exposure to air pollution may trigger non-specific abdominal pain in young individuals.
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Registered trials
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