ArticlePloS one2012
Sequence evolution of the intrinsically disordered and globular domains of a model viral oncoprotein.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Vital for Viruses: Intrinsically Disordered Proteins.Journal of molecular biology · 2023Review
- HPV16 E7 Nucleotide Variants Found in Cancer-Free Subjects Affect E7 Protein Expression and Transformation.Cancers · 2022Article
- Characterization of the High-Affinity Fuzzy Complex between the Disordered Domain of the E7 Oncoprotein from High-Risk HPV and the TAZ2 Domain of CBP.Biochemistry · 2021Article
- Modeling and Molecular Dynamics of the 3D Structure of the HPV16 E7 Protein and Its Variants.International journal of molecular sciences · 2021Article
- Degenerate cysteine patterns mediate two redox sensing mechanisms in the papillomavirus E7 oncoprotein.Redox biology · 2017Article
- Rapid evolution of virus sequences in intrinsically disordered protein regions.PLoS pathogens · 2014Article
- Translational fusion and redirection to thylakoid lumen as strategies to enhance accumulation of human papillomavirus E7 antigen in tobacco chloroplasts.Molecular biotechnology · 2014Article
- The human papillomavirus E7 proteins associate with p190RhoGAP and alter its function.Journal of virology · 2014Article
- Computational biophysical, biochemical, and evolutionary signature of human R-spondin family proteins, the member of canonical Wnt/β-catenin signaling pathway.BioMed research international · 2014Article
- DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor.BioMed research international · 2014Article
- A decade and a half of protein intrinsic disorder: biology still waits for physics.Protein science : a publication of the Protein Society · 2013Review
- Minute time scale prolyl isomerization governs antibody recognition of an intrinsically disordered immunodominant epitope.The Journal of biological chemistry · 2013Article
- Intrinsically disordered regions of p53 family are highly diversified in evolution.Biochimica et biophysica acta · 2013Article
- A comparative study of Whi5 and retinoblastoma proteins: from sequence and structure analysis to intracellular networks.Frontiers in physiology · 2013Article
- Conformational dissection of a viral intrinsically disordered domain involved in cellular transformation.PloS one · 2013Article
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Authors and funding
6 authors.
Funding
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Abstract
In the present work, we have used the papillomavirus E7 oncoprotein to pursue structure-function and evolutionary studies that take into account intrinsic disorder and the conformational diversity of globular domains. The intrinsically disordered (E7N) and globular (E7C) domains of E7 show similar degrees of conservation and co-evolution. We found that E7N can be described in terms of conserved and coevolving linear motifs separated by variable linkers, while sequence evolution of E7C is compatible with the known homodimeric structure yet suggests other activities for the domain. Within E7N, inter-residue relationships such as residue co-evolution and restricted intermotif distances map functional coupling and co-occurrence of linear motifs that evolve in a coordinate manner. Within E7C, additional cysteine residues proximal to the zinc-binding site may allow redox regulation of E7 function. Moreover, we describe a conserved binding site for disordered domains on the surface of E7C and suggest a putative target linear motif. Both homodimerization and peptide binding activities of E7C are also present in the distantly related host PHD domains, showing that these two proteins share not only structural homology but also functional similarities, and strengthening the view that they evolved from a common ancestor. Finally, we integrate the multiple activities and conformations of E7 into a hierarchy of structure-function relationships.
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