Evidence map›Paper›PMID 23118877›Full record

ArticlePloS one2012

Mortality, severe acute respiratory infection, and influenza-like illness associated with influenza A(H1N1)pdm09 in Argentina, 2009.

Eduardo Azziz-Baumgartner, Ana María Cabrera, Loretta Chang, Rogelio Calli, Gabriela Kusznierz, Clarisa Baez, Pablo Yedlin, Ana María Zamora, Romina Cuezzo, Elena Beatriz Sarrouf and 13 more

Abstract read
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Factors affecting immune responses to the influenza vaccine.Human vaccines & immunotherapeutics · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Eduardo Azziz-BaumgartnerInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Ana María Cabrera
Loretta Chang
Rogelio Calli
Gabriela Kusznierz
Clarisa Baez
Pablo Yedlin
Ana María Zamora
Romina Cuezzo
Elena Beatriz Sarrouf
Andrea Uboldi
Juan Herrmann
Elsa Zerbini
Osvaldo Uez
Pedro Osvaldo Rico Cordeiro
Pollyanna Chavez
George Han
Julián Antman
Fatima Coronado
Joseph Bresee
Marina Kosacoff
Marc-Alain Widdowson
Horacio Echenique

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhile there is much information about the burden of influenza A(H1N1)pdm09 in North America, little data exist on its burden in South America.

methodsDuring April to December 2009, we actively searched for persons with severe acute respiratory infection and influenza-like illness (ILI) in three sentinel cities. A proportion of case-patients provided swabs for influenza testing. We estimated the number of case-patients that would have tested positive for influenza by multiplying the number of untested case-patients by the proportion who tested positive. We estimated rates by dividing the estimated number of case-patients by the census population after adjusting for the proportion of case-patients with missing illness onset information and ILI case-patients who visited physicians multiple times for one illness event.

resultsWe estimated that the influenza A(H1N1)pdm09 mortality rate per 100,000 person-years (py) ranged from 1.5 among persons aged 5-44 years to 5.6 among persons aged ≥ 65 years. A(H1N1)pdm09 hospitalization rates per 100,000 py ranged between 26.9 among children aged <5 years to 41.8 among persons aged ≥ 65 years. Influenza A(H1N1)pdm09 ILI rates per 100 py ranged between 1.6 among children aged <5 to 17.1 among persons aged 45-64 years. While 9 (53%) of 17 influenza A(H1N1)pdm09 decedents with available data had obesity and 7 (17%) of 40 had diabetes, less than 4% of surviving influenza A(H1N1)pdm09 case-patients had these pre-existing conditions (p ≤ 0.001).

conclusionInfluenza A(H1N1)pdm09 caused a similar burden of disease in Argentina as in other countries. Such disease burden suggests the potential value of timely influenza vaccinations.

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza, HumanSevere Acute Respiratory SyndromeAdolescentAdultArgentinaChildChild, PreschoolFemaleHospitalizationHumansInfantMaleMiddle AgedPandemics

Identifiers

PMID23118877
PMCPMC3485247

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.