ArticlePloS one2012
FMRI activity in the macaque cerebellum evoked by intracortical microstimulation of the primary somatosensory cortex: evidence for polysynaptic propagation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Cerebro-cerebellar interactions in nonhuman primates examined by optogenetic functional magnetic resonance imaging.Cerebral cortex communications · 2022Article
- Dissecting the Prefrontal Network With Pathway-Selective Manipulation in the Macaque Brain-A Review.Frontiers in neuroscience · 2022Review
- High-resolution mapping and digital atlas of subcortical regions in the macaque monkey based on matched MAP-MRI and histology.NeuroImage · 2021Article
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- The detailed organization of the human cerebellum estimated by intrinsic functional connectivity within the individual.Journal of neurophysiology · 2021Article
- Mouse optical imaging for understanding resting-state functional connectivity in human fMRI.Communicative & integrative biology · 2018Review
- Effective Connectivity Measured Using Optogenetically Evoked Hemodynamic Signals Exhibits Topography Distinct from Resting State Functional Connectivity in the Mouse.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Activation of Direct and Indirect Pathway Medium Spiny Neurons Drives Distinct Brain-wide Responses.Neuron · 2016Article
- Transient neuronal coactivations embedded in globally propagating waves underlie resting-state functional connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Mapping Horizontal Spread of Activity in Monkey Motor Cortex Using Single Pulse Microstimulation.Frontiers in neural circuits · 2016Article
- Dynamically Allocated Hub in Task-Evoked Network Predicts the Vulnerable Prefrontal Locus for Contextual Memory Retrieval in Macaques.PLoS biology · 2015Article
- Monkey cortex through fMRI glasses.Neuron · 2014Review
- Dissociable memory traces within the macaque medial temporal lobe predict subsequent recognition performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Simultaneous electrical microstimulation (EM) and functional magnetic resonance imaging (fMRI) is a useful tool for probing connectivity across brain areas in vivo. However, it is not clear whether intracortical EM can evoke blood-oxygenation-level-dependent (BOLD) signal in areas connected polysynaptically to the stimulated site. To test for the presence of the BOLD activity evoked by polysynaptic propagation of the EM signal, we conducted simultaneous fMRI and EM in the primary somatosensory cortex (S1) of macaque monkeys. We in fact observed BOLD activations in the contralateral cerebellum which is connected to the stimulation site (i.e. S1) only through polysynaptic pathways. Furthermore, the magnitude of cerebellar activations was dependent on the current amplitude of the EM, confirming the EM is the cause of the cerebellar activations. These results suggest the importance of considering polysynaptic signal propagation, particularly via pathways including subcortical structures, for correctly interpreting 'functional connectivity' as assessed by simultaneous EM and fMRI.
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