ArticlePloS one2012
The role of the bHLH protein hairy in morphogenetic furrow progression in the developing Drosophila eye.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Extramacrochaetae regulates Notch signaling in thebioRxiv : the preprint server for biology · 2024Article
- The Id protein Extramacrochaetae restrains the E protein Daughterless to regulate Notch, Rap1, and Sevenless within the R7 equivalence group of the Drosophila eye.Biology open · 2024Article
- Hexagonal patterning of the Drosophila eye.Developmental biology · 2021Review
- Daughterless, theDisease models & mechanisms · 2020Article
- Novel approach to quantitative spatial gene expression uncovers genetic stochasticity in the developing Drosophila eye.Evolution & development · 2019Article
- Comparative Transcriptomics in Two Extreme Neopterans Reveals General Trends in the Evolution of Modern Insects.iScience · 2018Article
- Article
- The Notch pathway regulates the Second Mitotic Wave cell cycle independently of bHLH proteins.Developmental biology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In Drosophila eye development, a wave of differentiation follows a morphogenetic furrow progressing across the eye imaginal disc. This is subject to negative regulation attributed to the HLH repressor proteins Hairy and Extramacrochaete. Recent studies identify negative feedback on the bHLH gene daughterless as one of the main functions of extramacrochaete. Here the role of hairy was assessed in relation to daughterless and other HLH genes. Hairy was not found to regulate the expression of Daughterless, Extramacrochaete or Atonal, and Hairy expression was largely unregulated by these other genes. Null alleles of hairy did not alter the rate or pattern of differentiation, either alone or in the absence of Extramacrochaete. These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila, alone or redundantly with extramacrochaete.
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Registered trials
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