ArticlePloS one2012
A fish-specific transposable element shapes the repertoire of p53 target genes in zebrafish.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Epigenomic analysis reveals prevalent contribution of transposable elements toGenome research · 2022Article
- Mobile Elements in Ray-Finned Fish Genomes.Life (Basel, Switzerland) · 2020Review
- TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells.Science advances · 2019Article
- A novel dominant-negative FGFR1 variant causes Hartsfield syndrome by deregulating RAS/ERK1/2 pathway.European journal of human genetics : EJHG · 2019Article
- Identification of p53-target genes in Danio rerio.Scientific reports · 2016Article
- Endogenous Retroviruses in Fish Genomes: From Relics of Past Infections to Evolutionary Innovations?Frontiers in microbiology · 2016Article
- Effects of heat and UV radiation on the mobilization of transposon mariner-Mos1.Cell stress & chaperones · 2015Article
- Evolutionary impact of transposable elements on genomic diversity and lineage-specific innovation in vertebrates.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation.PLoS genetics · 2015Article
- Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay.PloS one · 2015Article
- Gene regulatory evolution and the origin of macroevolutionary novelties: insights from the neural crest.Genesis (New York, N.Y. : 2000) · 2013Review
- Exaptation of transposable elements into novel cis-regulatory elements: is the evidence always strong?Molecular biology and evolution · 2013Review
- Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposable elements, as major components of most eukaryotic organisms' genomes, define their structural organization and plasticity. They supply host genomes with functional elements, for example, binding sites of the pleiotropic master transcription factor p53 were identified in LINE1, Alu and LTR repeats in the human genome. Similarly, in this report we reveal the role of zebrafish (Danio rerio) EnSpmN6_DR non-autonomous DNA transposon in shaping the repertoire of the p53 target genes. The multiple copies of EnSpmN6_DR and their embedded p53 responsive elements drive in several instances p53-dependent transcriptional modulation of the adjacent gene, whose human orthologs were frequently previously annotated as p53 targets. These transposons define predominantly a set of target genes whose human orthologs contribute to neuronal morphogenesis, axonogenesis, synaptic transmission and the regulation of programmed cell death. Consistent with these biological functions the orthologs of the EnSpmN6_DR-colonized loci are enriched for genes expressed in the amygdala, the hippocampus and the brain cortex. Our data pinpoint a remarkable example of convergent evolution: the exaptation of lineage-specific transposons to shape p53-regulated neuronal morphogenesis-related pathways in both a hominid and a teleost fish.
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